Bleomycin chemical structure
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Bleomycin

Bleomycin is an anti-cancer agent. It is a glycosylated linear nonribosomal peptide antibiotic produced by the bacterium Streptomyces verticillus. The drug is used in the treatment of lymphomas (especially Hodgkin's disease), squamous cell carcinomas, and testicular cancer as well as pleurodesis. more...

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History

Bleomycin was first discovered in 1962 when the Japanese scientist Hamao Umezawa found anti-cancer activity while screening culture filtrates of S. verticullus. Umezawa published his discovery in 1966. The drug was launched in Japan by Nippon Kayaku in 1969. In the US bleomycin gained FDA approval in July 1973. It was initially marketed in the US by the Bristol-Myers Squibb precursor Bristol Laboratories under the brand name Blenoxane.

Suppliers

Bristol-Myers Squibb still supplies Blenoxane. There are also generic versions of bleomycin available from Bedford, Sicor and Mayne Pharma.

Mechanism of action

Bleomycine acts by induction of DNA strand breaks. Some studies suggest that bleomycin also inhibits incorporation of thymidine into DNA strands. Bleomycin is a metal-chelating molecule that is also thought to produce superoxide and hydroxide free radicals, through action as a pseudoenzyme, which also damage the DNA.

Side effects

The most serious complication of bleomycin is pulmonary fibrosis and impaired lung function. Other side-effects include fever, rash, hyperpigmentation, alopecia, and Raynaud's phenomenon.

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Analogues of bleomycin and firefly luciferin : (Dissertation) $55.00 Gale Encyclopedia of Cancer : Bleomycin $2.30
Radical-Promoting Loosely-Bound Iron in Biological Fluids and the Bleomycin Assay (Life Chemistry Reports Series) $175.47

Alveolar Surfactant Protein D Content Modulates Bleomycin-induced Lung Injury
Rationale: Surfactant protein D (SP-D) is a collectin family member with demonstrated immunomodulatory properties in vitro. We hypothesized that SP-D modulates inflammation during noninfectious lung
Influence of inhaled dexamethasone on the bleomycin-induced lung fibrosis in rats
PURPOSE: To compare the effect and mechanism of inhaled with systemic dexamethasone on the bleomycin-induced lung fibrosis in rats. METHODS: 60 Sprague-Dawley ...
Attenuation of Bleomycin-induced Pulmonary Fibrosis by Follistatin
Rationale: Activins are members of the transforming growth factor-β superfamily thought to be involved in repair processes after tissue injury. Objectives: ...
Imatinib as a Novel Antifibrotic Agent in Bleomycin-induced Pulmonary Fibrosis in Mice
Imatinib mesylate is a potent and specific tyrosine kinase inhibitor against c-ABL, BCR-ABL, and c-KIT, and has been demonstrated to be highly active in chronic myeloid leukemia and gastrointestinal
Bleomycin-Induced Pneumonitis - )
The cytotoxic agent bleomycin is feared for its induction of sometimes fatal pulmonary toxicity, also known as bleomycin-induced pneumonitis (BIP). The central event in the development of BIP is en
CXCL11 Attenuates Bleomycin-induced Pulmonary Fibrosis via Inhibition of Vascular Remodeling
Aberrant vascular remodeling is a central hallmark for the development and progression of idiopathic pulmonary fibrosis. The mechanisms underlying the ...
Simultaneous acral nodular eruption and flagellate erythema caused by bleomycin
Abstract A 29-year-old male with AIDS was treated with bleomycin and vincristine for visceral Kaposi's sarcoma. Three days later, he developed two ...
Treatment Of Symptomatic Malignant Pleural Effusions With Bleomycin - Abstract
Shabir Bhimji, MD(*) and Lionel Zumbro, MD. Cardiothoracic Surgery, Medical College of Georgia, Augusta, GA. PURPOSE: The optimal duration and treatment ...

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