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Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension Study objectives: We performed an open-label multicenter study to evaluate the safety and efficacy of the dual endothelin receptor antagonist bosentan ... From CHEST, 10/1/05 by Marius M. Hoeper

Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension Background: Bosentan, an oral endothelin (ET)-A/ET-B receptor antagonist, is effective in the treatment of pulmonary arterial hypertension. Objective: ... From CHEST, 10/1/05 by Diana Bonderman

Case report: bosentan-resistant sarcoidosis-associated pulmonary hypertension responsive to sildenafil INTRODUCTION: Pulmonary hypertension in sarcoidosis has been attributed to end-stage lung fibrosis with resultant destruction of pulmonary vasculature(1), ... From CHEST, 10/1/05 by Haroon A. Faraz

Breathe-5: Bosentan improves hemodynamics and exercise capacity in the first randomized placebo-controlled trial in Eisenmenger physiology PURPOSE: BREATHE-5 was the first placebo-controlled trial to investigate the effects of bosentan (Tracleer[R]) in patients with Eisenmenger physiology ... From CHEST, 10/1/05 by Nazzareno Galie

Pulmonary hypertension in the elderly: demographics and outcomes following therapy with bosentan PURPOSE: Pulmonary hypertension (PH) is typically a disease of young women. The use of screening echocardiograms has increased the detection of PH in ... From CHEST, 10/1/05 by Maria Carrillo

Sildenafil equal to bosentan in pulmonary hypertension therapy Clinical Question: Is sildenafil (Viagra) more effective than bosentan (Tracleer) in the treatment of patients with class III pulmonary hypertension? From American Family Physician, 10/1/05 by Henry Barry

Long term experience with bosentan in patients with pulmonary arterial hypertension associated with advanced idiopathic pulmonary fibrosis and interstitial PURPOSE: Bosentan is an experimental antifibrotic agent and approved for the management of PAH. Patients with ILD often manifest PAH as pulmonary fibrosis ... From CHEST, 10/1/05 by Ganesh Raghu

The addition of sildenafil to bosentan therapy in the treatment of pulmonary arterial hypertension PURPOSE: Pulmonary arterial hypertension (PAH) is a progressive disease that often results in right heart failure and death. Combination therapy targeting ... From CHEST, 10/1/05 by Stephen C. Mathai

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