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Bronopol

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Overview

Bronopol (INN) is a highly active antimicrobial chemical compound whose chemical formula is 2-bromo-2-nitropropane-1,3-diol.

Bronopol was invented by The Boots Company PLC, Nottingham, England in the early 1960s and first applications were as a preservative for pharmaceuticals. Bronopol's low mammalian toxicity (at in-use levels) and exceptional activity against bacteria (especially the troublesome Gram-negative species) ensured that it became popular as a preservative in many consumer products such as shampoos and cosmetics.

Bronopol was subsequently taken up as an effective antimicrobial in many industrial environments such as paper manufacturing, oil exploration and production and cooling water disinfection.

World production soared from the tens of tonnes in the late 1970s to current estimates in excess of 5,000 tonnes. This is quite something considering the effective use-concentration which can be as low as 0.0025% (25 parts per million). Manufacturing today is the business of low cost producers, mainly in China.

Pharmaceutical products containing Bronopol are registered in a number of countries and Bronopol is the subject of a specific monograph in the British Pharmacopoeia 1998.

Applications

Today, Bronopol is used in consumer products as an effective preservative agent, as well as a wide variety of industrial applications (almost any industrial water system is a potential environment for bacterial growth, leading to slime and corrosion problems - in many of these systems Bronopol can be a highly effective treatment).

The use of Bronopol in personal care products (cosmetics, toiletries) has declined since the late 1980s due to the recognised potential for nitrosamine formation.

The Nitrosamine Problem

Although fairly ubiquitous in our diet and the environment, and even produced within the stomach from various foodstuffs, many nitrosamines are known or suspect carcinogens and therefore should be avoided in manufactured goods.

Nitrosamines are relatively easily produced from secondary amines and amides in the presence of nitrite ions (this is why they are formed in-vivo from foodstuffs).

While Bronopol is not in itself a nitrosating agent, under conditions where it decomposes (alkaline solution and/or elevated temperatures) it can liberate nitrite and low levels of formaldehyde and these decomposition products can react with any contaminant secondary amines or amides in a personal care formulation to produce significant levels of nitrosamines (due to the toxicity of thes substances, the term 'significant' means levels as low as 10s of parts per billion).

Manufacturers of personal care products are therefore instructed by regulatory authorities to 'avoid the formation of nitrosamines' which might mean removing amines or amides from the formulation, removing Bronopol from a formulation, or using nitrosamine inhibitors.

Read more at Wikipedia.org


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