X-Ray of the knee in a patient with dermatomyositis.
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Dermatomyositis

Dermatomyositis is connective-tissue disease that is characterized by inflammation of the muscles and the skin. Its cause is unknown, but it may result from either a viral infection or an autoimmune reaction. Up to 50% of the cases may be a paraneoplastic phenomenon, indicating the presence of cancer.

X-ray findings include dystrophic calcifications in the muscles.

There is a form of this disorder that strikes children, known as juvenile dermatomyositis.

"Gottron's papules", pink patches on the knuckles, are associated with this disorder.

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Infliximab to treat dermatomyositis and polymyositis
From Journal of Drugs in Dermatology, 7/1/05

This study is currently recruiting patients. Sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). This study will examine whether infliximab (Remicade) is safe and effective for the treatment of dermatomyositis and polymyositis. Infliximab blocks the effect of a protein called tumor necrosis factor (TNF), which is associated with harmful inflammation in many diseases.

Study ID Numbers: 020156; 02-AR-0156

ClinicalTrials.gov Identifier: NCT00033891

COPYRIGHT 2005 Journal of Drugs in Dermatology, Inc.
COPYRIGHT 2005 Gale Group

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