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Diverticulitis

Diverticulitis is a common disease of the bowel, in particular the large intestine. Diverticulitis develops from diverticulosis, which involves the formation of pouches (diverticula) on the outside of the colon. Diverticulitis results if one of these diverticulum becomes inflamed. more...

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Complications

In complicated diverticulitis, bacteria may subsequently infect the outside of the colon if an inflamed diverticulum bursts open. If the infection spreads to the lining of the abdominal cavity, (peritoneum), this can cause a potentially fatal peritonitis. Sometimes inflamed diverticula can cause narrowing of the bowel, leading to an obstruction. Also, the affected part of the colon could adhere to the bladder or other organ in the pelvic area, causing a fistula, or abnormal communication between the colon and an adjacent organ.

Incidence

Diverticulitis most often affects middle-aged and elderly persons, though it can strike younger patients as well.

In Western countries, diverticular disease most commonly involves the sigmoid colon (95% of patients). The prevalence of diverticular disease has increased from an estimated 10% in the 1920s to between 35 and 50% by the late 1960s. 65% of those currently 85 years of age and older can be expected to have some form of diverticular disease of the colon. Less than 5% of those aged 40 years and younger may also be affected by diverticular disease.

Left-sided diverticular disease (involving the sigmoid colon) is most common in the West, while right-sided diverticular disease is more prevalent in Asia and Africa.

Among patients with diverticulosis, 10-25% patients will go on to develop diverticulitis within their lifetimes.

Causes

The development of colonic diverticulum is thought to be a result of raised intraluminal colonic pressures. The sigmoid colon has the smallest diameter of any portion of the colon, and therefore the portion which would be expected to have the highest intraluminal pressure according to the laws of Laplace. The postulate that low dietary fiber, particularly non-soluble fiber (also known in older parlance as "roughage") predisposes individuals to diverticular disease is supported within the medical literature.

It is thought that mechanical blockage of a diverticulum, possibly by a piece of feces, leads to infection of the diverticulum.

Presentation

Patients often present with the classic triad of left lower quadrant pain, fever, and leukocytosis (an elevation of the white cell count in blood tests). Patients may also complain of nausea or diarrhea; others may be constipated.

Less commonly, an individual with diverticulitis may present with right-sided abdominal pain. This may be due to the less prevalent right-sided diverticula or a very redundant sigmoid colon.

Diagnosis

The differential diagnosis includes colon cancer, inflammatory bowel disease, ischemic colitis, and irritable bowel syndrome, as well as a number of urological and gynecological processes. Some patients report bleeding from the rectum.

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Diverticulosis and diverticulitis - Fact Sheet - Pamphlet
From Pamphlet by: National Institute of Diabetes & Digestive & Kidney Diseases, 10/1/91

Diverticulosis is a condition in which outpouchings form in the walls of the intestines. These pouches, known as diverticula, are about the size of large peas. They form in weakened areas of the bowels, most often in the lower part of the colon (large bowel). (See figure 1.)

What Are the Symptoms of Diverticulosis?

Most people with diverticula do not have any symptoms from them. They may never know they have the condition. Some people feel tenderness over the affected area or muscle spasms in the abdomen. Pain may be felt on the lower left side of the abdomen or, less often, in the middle or on the right side.

Although the diverticula themselves do not cause symptoms, complications such as bleeding and infection may occur. Bleeding is an uncommon symptom and is usually not severe. Sometimes the pouches become infected and inflamed, a more serious condition known as diverticulitis. (See figure 2.) When inflammation is present, there may be fever and an increased white blood cell count, as well as acute abdominal pain. Diverticulitis also may result in large abscesses (infected areas of pus), bowel blockage, or breaks and leaks through the bowel wall.

How Are These Disorders Diagnosed?

Often diverticulosis is unsuspected and is discovered by an x-ray or intestinal examination done for an unrelated reason. The doctor may see the diverticula through a flexible tube (colonoscope) that is inserted through the anus. Through this scope, the diverticula may be seen as dark passages leading out of the normal colon wall. The doctor also may do a barium enema, an x-ray that reveals the outpouchings in the walls of the colon.

If rectal bleeding occurs, the doctor may take a special x-ray (angiography). In this procedure, dye is injected into an artery that goes to the colon, so that the site of the bleeding problem can be located. Diverticulitis may be diagnosed when a patient has pain and tenderness in the lower abdomen with disturbed bowel function and fever.

How Common Are These Disorders?

Diverticulosis is very common, especially in older people. Studies show that about 10 percent of people over the age of 40 and nearly half of people over age 60 have diverticulosis. But among those who are found to have diverticula, only about 20 percent develop diverticulitis, and of those, only a small number have very serious or life-threatening complications.

What Causes Diverticula To Form?

No one knows for sure why the pouches form. Scientists think they may be caused by increased pressure inside the colon due to muscle spasms or straining. The sacs might form when increased pressure acts on soft spots along the bowel wall, especially if the person has constipation problems or uses laxatives too often.

How Serious Are These Disorders?

For most people, diverticulosis is not a problem. Diverticulitis, on the other hand, is a problem, sometimes a serious one. (See figure 2.) For instance, when one of the sacs (a diverticulum) becomes infected and inflamed, bacteria enter small tears in the surface of the bowel. This leads to small abscesses. Such an infection may remain localized and go away within a few days. In rare cases, the infection spreads and breaks through the wall of the colon causing peritonitis (infection of the abdominal cavity) or abscesses in the abdomen. Such infections are very serious and can lead to death unless treated without delay.

What Are the Treatments?

If you have diverticulosis with no symptoms, no treatment is needed. Some doctors advise eating a high-fiber diet and avoiding certain foods. Laxatives and enemas should not be used regularly. Patients with diverticulitis may be hospitalized and treated with bed rest, pain relievers, antibiotics, fluids given by vein, and careful monitoring.

Is Surgery Ever Necessary?

The majority of patients will recover from diverticulitis without surgery. Sometimes patients need surgery to drain an abscess that has resulted from a ruptured diverticulum and to remove that portion of the colon. Surgery is reserved for patients with very severe or multiple attacks. In those cases, the involved segment of colon can be removed and the colon rejoined.

In some cases, the two ends of the colon cannot be rejoined right away, so more than one operation is needed. For instance, an operation may be performed to drain an abscess and remove diseased colon and a second operation done to rejoin the colon. In this case, the surgeon must connect the colon to a surgically created hole on the body's surface (colostomy) until a second operation can be done to reconnect the colon.

The delay between operations may be only a few weeks, or it might be several months if the patient needs time to overcome infection and build up strength. In rare cases, three operations are needed: the first to drain an abscess, the second to remove part of the colon, and the third to rejoin the bowel.

What About Diet?

If you have diverticulosis with no symptoms, you don't need treatment, but it is a good idea to watch your diet. The diet some doctors recommend is the same kind that is healthy for most people--eat more foods high in fiber. (See Diet, Nutrition & Cancer Prevention: The Good News in the additional readings section.) A fiber-rich diet helps prevent constipation and promotes a healthy digestive tract. Fiber-rich foods include whole-grain cereals and breads, fruits, and vegetables. A fiber-rich diet is also thought to help prevent diverticula from forming.

Remember, diverticula usually cause no problems at all, so a diagnosis of diverticulosis should not be a serious concern.

Additional Readings

Diet, Nutrition & Cancer Prevention: The Good News (NIH Publication No. 87-2878). Pamphlet available from the Cancer Information Service, Office of Cancer Communications, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892. 1-800-4-CANCER. Discusses high-fiber diet and fiber-rich foods.

Diverticulitis and Diverticulosis. Fact sheets available from the National Organization for Rare Disorders, Inc., P.O. Box 8923, New Fairfield, CT 06812-1783. (203) 746-6518.

Ertan A. Colonic diverticulitis: recognizing and managing its presentations and complications. Post-graduate Medicine 1990; 88(3): 67-72, 77. This article for primary care physicians discusses how to recognize, evaluate, and manage diverticulitis.

Larson DE, Editor-in-chief Mayo Clinic Family Health Book. New York: William Morrow and Company, Inc., 1990. General medical guide with section on diverticular disease. Available in libraries and bookstores.

Weck E. New hope for those with diverticular disease. FDA Consumer 1987; 21(6): 23-5. Article reprint available from the Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857 or in libraries.

National Digestive Diseases Information Clearinghouse

Box NDDIC

9000 Rockville Pike

Bethesda, MD 20892

(301) 468-6344

The National Digestive Diseases Information Clearinghouse is a service of the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health, under the U.S. Public Health Service. The clearinghouse was authorized by Congress to focus a national effort on providing information to the public, patients and their families, and doctors and other health care professionals. The clearinghouse works with organizations to educate people about digestive health and disease. The clearinghouse answers inquiries; develops, reviews, and distributes publications; and coordinates informational resources about digestive diseases.

Publications produced by the clearinghouse are reviewed carefully for scientific accuracy, appropriateness of content, and readability. Publications produced by sources other than the clearinghouse are also reviewed for scientific accuracy and are used, along with clearinghouse publications, to answer requests.

This publication is not copyrighted. The clearinghouse urges users of this fact sheet to duplicate and distribute as many copies as desired.

COPYRIGHT 1991 National Institute of Diabetes & Digestive & Kidney Diseases
COPYRIGHT 2004 Gale Group

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