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Elidel

Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis (eczema). It is currently available as a topical cream, marketed by Novartis, under the trade name Elidel®. more...

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In January, 2006, the United States Food and Drug Administration (FDA) announced that Elidel packaging would be required to carry a black box warning regarding the potential increased risk of lymph node or skin malignancy.

Pharmacology

Pimecrolimus is an ascomycin macrolactam derivative. It has been shown in vitro that pimecrolimus binds to macrophilin-12 and inhibits calcineurin. Thus pimecrolimus inhibits T-cell activation by inhibiting the synthesis and release of cytokines from T-cells. Pimecrolimus also prevents the release of inflammatory cytokines and mediators from mast cells.

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	New study demonstrates importance of Elidel in steroid allergic or intolerant patients A recent randomized, double-blinded vehicle-controlled study demonstrated the importance of Elidel cream for the treatment of facial eczema in patients ... From Journal of Drugs in Dermatology, 1/1/06

	Elidel-study This study is currently recruiting patients. Sponsored by Dresden University of Technology. Atopic dermatitis is a common disease. Emollients and Elidel ... From Journal of Drugs in Dermatology, 11/1/05

	Efficacy of Elidel cream on erosive oral lichen planus This study is currently recruiting patients. Sponsored by University Hospital Tuebingen. The purpose of this study is to investigate whether topical ... From Journal of Drugs in Dermatology, 1/1/06

	Efficacy of Elidel cream on erosive oral lichen planus This study is currently recruiting patients. Sponsored by University Hospital Tuebingen. The purpose of this study is to investigate whether topical ... From Journal of Drugs in Dermatology, 11/1/05

	Understanding eczema: soothe scaly patches—and get your skin in balance—with this expert advice - BeautyRx More than 15 million Americans suffer from eczema--a chronic skin disorder that causes patches of dry, itchy, red skin--according to the American Academy ... From Shape, 12/1/03 by Jody Buffalo

	What is the role of tacrolimus and pimecrolimus in atopic dermatitis? EVIDENCE-BASED ANSWER When the standard therapies--mild topical corticosteroids and moisturizers--fail in the treatment of atopic dermatitis, patients ... From Journal of Family Practice, 8/1/05 by Sara Trammell

	Other FDA advisories Other FDA Advisories: Recall of urine processing kit. The U.S. Food and Drug Administration (FDA) has issued a Class I recall of the ProbeTec ET Urine ... From American Family Physician, 6/1/05

	DC Online Flu Shot Disappointments U.S. Researchers attempting to quantify the number of lives that have been saved by influenza vaccines have come up with a disappointing ... From Dynamic Chiropractic, 5/21/05 by Sutton, Brian

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