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Esmolol

Esmolol (tradename Brevibloc®) is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages. more...

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Esmolol decreases the force and rate of heart contractions by blocking beta-adrenergic receptors of the sympathetic nervous system, which are found in the heart, lungs and other organs of the body. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine.

Dosing

Esmolol is given by slow intravenous injection. It is commonly used in patients during surgery to prevent or treat tachycardia, and is also used in treatment of supraventricular tachycardia.

Metabolism

Esmolol is rapidly hydrolysed by the esterases in the cytosol of red blood cells. Plasma cholinesterases and red cell membrane acetylcholinesterase do not have any action. This metabolism results in the formation of a free acid and methanol. The amount of methanol produced is similar to endogenous methanol production. Its elimination half-life is about 9 minutes.


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Esmolol: A review of the first intravenous ultra-short acting beta blocker ([Little blue book]) Esmolol, a novel ultra-short-acting beta-blocking agent (The Journal of clinical pharmacology) (The Journal of clinical pharmacology)

A comparison of esmolol & diltiazem for heart rate control during coronary revascularisation on beating heart
This prospective study was done to compare the control of heart rate and haemodynamics during coronary artery revascularisation without cardiopulmonary ...
Efficacy Of Esmolol Versus Diltiazem For Treatment Of Atrial Fibrillation/Flutter Following Heart Surgery - Abstract
Purpose: This prospective, randomized, open label study was designed to compare the efficacy of IV esmolol (IVE) vs. IV diltiazem (IVD) for the treatment ...
Pharmacologic control of ventricular rate : American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation
While there is a deficiency in the number of randomized control studies dealing with the pharmacologic control of the ventricular response to atrial ...
Pharmacologic control of rhythm : American College of chest physicians guidelines for the prevention and management of postoperative atrial fibrillation
Of the 128 articles evaluated on the overall topic of atrial fibrillation (AF) after cardiac surgery, only 19 studies dealing with pharmacologic heart ...
Report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents
The National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents has issued its Fourth Report on the Diagnosis, Evaluation, and Treatment of High
Esmolol in the treatment of multifocal atrial tachycardia
Multifocal atrial tachycardia (MAT) is a supraventricular tachydysrhythmia precipitated by a number of pharmacologic and physiologic disturbances. Corrections of these disturbances should take pre
Influence of alterations in loading on mitral annular velocity by tissue Doppler echocardiography and its associated ability to predict filling pressures
Study objectives: Early diastolic mitral annular velocity (E') by tissue Doppler echocardiography (TD) has been reported to be a load-independent index ...
Aortic dissection: the tear that kills
This deadly cardiac condition requires rapid identification and immediate medical intervention. Abstract: Patient survival of aortic dis section hinges ...

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