Structural formula of estrone
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Estrone

Estrone is an estrogenic hormone secreted by the ovary. Its molecular formula is C18H22O2. Estrone has a melting point of 254.5 degrees Celsius.

Synthesis

Estrone is synthesized from androstenedione, a derivative of progesterone. The conversion consists of the de-methylation of C-19 and the aromaticity of the 'A' ring. This reaction is similar to the conversion of testosterone to estradiol.

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