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Famotidine

Famotidine is a histamine H₂-receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). more...

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Clinical use

Certain preparations of famotidine are available over the counter (OTC) in various countries. In the United States, preparations of 10 mg and 20mg tablets, sometimes in combination with a more traditional antacid (brand name Pepcid Complete), are available OTC. Larger doses still require a prescription.

History and development

Famotidine was developed by Merck & Co.. The imidazole-ring of cimetidine was replaced with a 2-guanidinothiazole ring. Famotidine proved to be 30 times more active than cimetidine.

It was first marketed (as Pepcidine® and Pepcid®) in 1985. Pepcid RPD® (orally disintegrating tablets that are not swallowed) was released in 1999. Generic forms (e.g. Fluxid®, Schwarz Pharma) became available in 2001.

In the United States, a product called Pepcid Complete is available that combines famotidine with an antacid in a chewable tablet to ameliorate the relatively slow onset of effects.

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	Famotidine: A Further Development in the Modern Treatment of Peptic Ulcer Disease $21.94	Heartburn and wheezing may have something in common. : An article from: Medical Update $5.95

	Famotidine - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References $34.95


Perrigo Private label manufacturer Perrigo last month gained tentative approval from the Food and Drug Administration to manufacture and market OTC famotidine ... From Drug Store News, 10/10/05 by Michael Johnsen

Flurry of generic famotidine follows Pepcid patent loss - Andrx, Ivax, Myland and others launch their version - Brief Article - Statistical Data Included Andrx, Ivax, Mylan, Par Pharmaceuticals and Teva began marketing famotidine, the generic equivalent of Merck's Pepcid, just days after the drug's patent ... From Drug Store News, 5/21/01

Efficacy of famotidine in the prevention of ulcers - adapted from the New England Journal of Medicine 1996;334:1435-9 - Tips from Other Journals A common side effect of nonsteroidal anti-inflammatory drug (NSAID) therapy is gastroduodenal injury. Studies have demonstrated that famotidine, a histamine ... From American Family Physician, 9/15/96

Drugs, pregnancy, and lactation: GI agents: part I Gastrointestinal complaints are common in pregnancy and the postpartum period. They include conditions such as nausea and vomiting, constipation, diarrhea, ... From OB/GYN News, 11/15/05 by Gerald G. Briggs

Brand loyalty in heartburn relief keeps OTC switch sales on top There are more than 54 million sufferers of frequent heartburn and most of them are seeking treatment, so it's not surprising that consumers are still ... From Drug Store News, 10/24/05 by Michael Johnsen

Pancytopenia after a single intradermal infiltration of methotrexate Abstract Methotrexate-related hematologic toxicity may include leakopenia, thrombocytopenia, megaloblastic anemia, and pancytopenia. We report a woman ... From Journal of Drugs in Dermatology, 9/1/05 by Philip R. Cohen

Evaluation of Chronic Gastrointestinal Symptoms following Persian Gulf War Exposure This was a prospective study performed in a Department of Veterans Affairs Medical Center. The aim of this study was to use endoscopic and histological ... From Military Medicine, 8/1/05 by Koch, Timothy R

Heartburn and Ulcer Drug Pepcid Now Available as Generic - Brief Article The prescription drug Pepcid (famotidine), used for the short-term treatment of heartburn and peptic ulcers, is now available in generic form. The FDA ... From FDA Consumer, 7/1/01

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