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Fludarabine

Fludarabine is a chemotherapy drug used in the firstline treatment of chronic lymphocytic leukemia. Because of its immunosuppression, fludarabine is also used in some conditioning regimens of non myeloablative allogeneic transplant. more...

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It is a purine analog, and is given intravenously. Fludarabine inhibits DNA synthesis by interering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells.

Fludarabine is associated with profound lymphocytopenia, and as a consequence, increases the risk of opportunistic infections significantly.

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	Distinguish Fludarabine-Induced Lung Toxicity From Infection.(Brief Article) : An article from: Family Practice News $5.95	Gale Encyclopedia of Cancer : Fludarabine $3.10


Fludarabine-related pulmonary toxicity : a distinct clinical entity in chronic lymphoproliferative syndromes - clinical investigations Background: Little is known about lung injury caused by fludarabine therapy. Objectives: To establish a case definition, to describe management, and ... From CHEST, 9/1/02 by Donald L. Helman, Jr.

Distinguish Fludarabine-Induced Lung Toxicity From Infection - Brief Article BETHESDA, MD. -- The chemotherapy agent fludarabine can induce pulmonary toxicity that resembles the symptoms of pulmonary infection, Dr. Donald L. Helman reported at the annual meeting of the Wash From Family Pratice News, 4/15/00 by Mary Ann Moon

Leukemia drug approved - fludarabine approved for treatment of chronic lymphocytic leukemia FDA has approved fludarabine, an "orphan" drug that offers people with the most common form of adult leukemia--chronic lymphocytic leukemia, or CLL-an ... From FDA Consumer, 7/1/91

Fludarabine Definition Fludarabine is a chemotherapy medicine used to treat certain types of cancer by destroying cancerous cells. It is known as the ... From Gale Encyclopedia of Cancer, by R.Ph. Nancy J. Beaulieu, B.C.O.P.

Liver Biopsy Findings Following Donor Lymphocyte Infusion We present a case of a 49-year-old man previously diagnosed with chronic myelogenous leukemia. His bone marrow biopsy showed a complex triple translocation ... From Archives of Pathology & Laboratory Medicine, 8/1/05 by Wu, Shou-Jin

Hairy Cell Leukemia Variant With Features of Intrasinusoidal Bone Marrow Involvement Hairy cell leukemia variant (HCL-V) is a rare lymphoproliferative disorder. We report a case of HCL-V with an intrasinusoidal pattern of bone marrow involvement ... From Archives of Pathology & Laboratory Medicine, 3/1/05 by Ya-In, Charin

Pilot Clinical Study of Genasense® Plus Rituxan® and Fludarabine Shows Activity in Chronic Lymphocytic Leukemia Study Supports Safety and Potential Activity for the Regimen ATLANTA, Ga., Dec. 12 /PRNewswire-FirstCall/ -- Genta Incorporated announced the presentation ... From PR Newswire, 12/12/05

Peripheral stem cell transplantation plus monoclonal antibody therapy in treating patients with high-risk hematologic cancer, refractory breast or kidney This study is currently recruiting patients. Sponsored by Duke Comprehensive Cancer Center National Cancer Institute (NCI) Peripheral stem cell transplantation replaces immune cells that were d From Journal of Drugs in Dermatology, 11/1/04

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