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Fluorouracil

Fluorouracil (5-FU) is a drug that is used in the treatment of cancer. It belongs to the family of drugs called antimetabolites. It is a pyrimidine analog. Its principal use is in colorectal cancer, in which it has been the established form of chemotherapy for decades (platinum-containing drugs are a recent addition). more...

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As a pyrimidine analogue, it is transformed inside the cell into different cytotoxic metabolites which are then incorporated into DNA and RNA, finally inducing cell cycle arrest and apoptosis.

Capecitabine is a prodrug that is converted into 5-FU in the tissues. It can be administered orally.

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	Reticulate hyperpigmentation secondary to 5-fluorouracil and idarubicin.(CASE REPORTS) : An article from: Journal of Drugs in Dermatology $5.95	Neoadjuvant chemotherapy in squamous cell carcinoma of the esophagus using low dose continuous infusion 5-fluorouracil and cisplatin: results of a prospective ... : An article from: Indian Journal of Cancer $5.95

	Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy (Advances in Experimental Medicine and Biology) $138.00


5-Fluorouracil associated encephalopathy: Case report Byline: B. Yadav, S. Sharma Fluorouracil is an analogue of fluorinated pyramidine commonly used in the treatment of several cancers. After rapid intravenous ... From Indian Journal of Pharmacology, 3/1/05 by B. Yadav

Phase II study of combined 5-fluorouracil/ginkgo biloba extract therapy in 5-fluorouracil pretreated patients with advanced colorectal cancer - Gbe 761 Hauns B, Haring B, Kohler S, et al. Phytother Res 2001;15:34-38. The aim of the study was to evaluate the efficacy, tolerability and quality of life ... From Alternative Medicine Review, 6/1/02 by B Hauns

A randomized trial of topical 5% 5-fluorouracil in the treatment of actinic keratoses comparing daily with weekly treatment A Randomized Trial of Topical 5% 5-Fluorouracil (Efudix[R], Cream) in the Treatment of Actinic Keratoses Comparing Daily with Weekly Treatment Jury ... From Journal of Drugs in Dermatology, 1/1/06

5-Fluorouracil Infusion Reduces Gut-Associated Lymphoid Tissue Cell Number and Mucosal Immunoglobulin A Levels ABSTRACT. Background: Anticancer drugs have been demonstrated to affect gut mucosal morphology and cause gastrointestinal symptoms. We hypothesized that ... From JPEN: Journal of Parenteral and Enteral Nutrition, 11/1/05 by Nagayoshi, Hidetoshi

Reticulate hyperpigmentation secondary to 5-fluorouracil and idarubicin Abstract Although cutaneous reactions from antineoplastic therapy are common, a reticulate pattern of hyperpigmentation has not been frequently reported ... From Journal of Drugs in Dermatology, 9/1/05 by Reena Jogi

Physical and Chemical Stability of Palonosetron Hydrochloride with Fluorouracil and with Gemcitabine Hydrochloride During Simulated Y-Site Administration Abstract The objective of this study was to evaluate the physical and chemical stability of undiluted palonosetron 50 µg/mL as the hydrochloride with fluorouracil 16 mg/mL, and with gemcitabine 10 mg From International Journal of Pharmaceutical Compounding, 7/1/05 by Trissel, Lawrence A

Intralesional 5-fluorouracil in the treatment of keloids: an open clinical and histopathologic study Intralesional 5-Fluorouracil in the Treatment of Keloids: An Open Clinical and Histopathologic Study Kontochristopoulos G, MD, et al. Journal of the ... From Journal of Drugs in Dermatology, 7/1/05

Treatment of actinic keratoses with sequential combination of 5-fluorouracil and photodynamic therapy Abstract Actinic keratoses (AKs) are traditionally treated with cryotherapy, curettage, and 5-fluorouracil (5-FU, Efudex[R], ICN Pharmaceuticals, Inc.), all of which are associated with adverse e From Journal of Drugs in Dermatology, 3/1/05 by Dore J. Gilbert

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