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Gemcitabine

Gemcitabine is a nucleoside used as chemotherapy. It is marketed as Gemzar® by Eli Lilly and Company. more...

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Chemistry

Chemically gemcitabine is a nucleoside in which the hydrogens on the 2' carbon of deoxycytidine are replaced by fluorides.

Mode of action

As with fluorouracil and other analogues of pyrimidines, the drug replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as new nucleosides cannot be attached to the "faulty" nucleoside, resulting in apoptosis (cellular "suicide").

Uses

Gemcitabine is used in various carcinomas: non-small cell lung cancer, pancreatic cancer, and breast cancer. It is being investigated for use in oesophageal cancer, and is used experimentally in lymphomas and various other tumor types.

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	Gale Encyclopedia of Cancer : Gemcitabine $3.10	Gemcitabine-radiation Tx thwarts pancreatic Ca.(Gastroenterology) : An article from: Internal Medicine News $5.95


Phase II study of neoadjuvant chemotherapy with gemcitabine and vinorelbine in resectable non-small cell lung cancer Objective: We assessed the efficacy of a non-platinum-containing doublet chemotherapy of gemcitabine and vinorelbine as induction therapy prior to surgical ... From CHEST, 11/1/05 by Nithya Ramnath

Physical and Chemical Stability of Palonosetron Hydrochloride with Fluorouracil and with Gemcitabine Hydrochloride During Simulated Y-Site Administration Abstract The objective of this study was to evaluate the physical and chemical stability of undiluted palonosetron 50 µg/mL as the hydrochloride with fluorouracil 16 mg/mL, and with gemcitabine 10 mg From International Journal of Pharmaceutical Compounding, 7/1/05 by Trissel, Lawrence A

A Multicenter Phase II Trial of Vinorelbine Plus Gemcitabine in Previously Untreated Inoperable Non-small Cell Lung Cancer - Stage IIIB/IV - ) Study objective: Vinorelbine and gemcitabine are two active single agents used in the treatment of non-small cell lung cancer (NSCLC). A clinical trial ... From CHEST, 6/1/00 by Yuh-Min Chen

Fatal Pulmonary Toxicity Resulting From Treatment With Gemcitabine And Vinorelbine Association Purpose: Case 1: A 69 years old man had an extensive NSCLC. Gemcitabine (800 mg/m2) and vinorelbine (25 mg/m2) were given weekly. 7 days after the ninth ... From CHEST, 10/1/99 by Jean L Breton

Successful Treatment of Gemcitabine Toxicity With a Brief Course of Oral Corticosteroid Therapy - ) Gemcitabine is a nucleoside analog that is useful in the treatment of solid tumors. Its use has been postulated to produce lung injury by causing a capillary leak syndrome. We describe a gemcitabin From CHEST, 12/1/98 by Nicholas J. Vander Els

Azacitidine: A novel drug for myelodysplastic syndrome Byline: K. Mahesh Kumar Myelodysplastic syndrome (MDS)is a group of diseases showing different outcomes depending on its clinical presentations, which ... From Indian Journal of Pharmacology, 11/1/05 by K. Mahesh Kumar

Adjuvant chemotherapy for early-stage non-small cell lung cancer Lung cancer is the leading cause of cancer-related mortality in the developed world. Non-small cell lung cancer (NSCLC) represents 85% of cases of lung ... From CHEST, 10/1/05 by Antonio L. Visbal

Upper airway obstruction and respiratory failure caused by a paratracheal follicular dendritic cell tumor INTRODUCTION: Follicular dendritic cell (FDC) tumor is a rare neoplasm displaying immunophenotypic and morphological features of follicular dendritic ... From CHEST, 10/1/05 by Ali Hmidi

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