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Gemfibrozil

Gemfibrozil is the generic name for an oral lipid lowering drug. It is most commonly sold as the brand name, Lopid. more...

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Actions

  • Increase activity of Peroxisome proliferator-activated receptor-alpha (PPARĪ±), a receptor which is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation.

Therapeutic effects

  • Reduce triglyceride levels
  • Reduce Very low density lipoprotein (VLDL) levels
  • Modest reduction of Low density lipoprotein (LDL) levels
  • Moderate increase in High density lipoprotein (HDL) levels

Nontherapeutic effects and toxicities

  • GI distress
  • Musculoskeletal pain
  • Increased incidence of gallstones
  • Hypokalemia

Indications

  • Hyperlipidemia (Type III): Gemfibrozil is the drug of choice for therapy.
  • Hypertriglyceridemia (Type IV): Gemfibrozil, though not as effective as nicotinic acid, is better tolerated.

Contraindications and Precautions

  • Gemfibrozil should not be given to these patients:
    • Hepatic dysfunction
    • Renal dysfunction
  • Gemfibrozil should be used with caution in these higher risk categories:
    • Biliary tract disease
    • pregnant women
    • obese patients
    • Native Americans

Drug Interactions

  • Anticoagulants. Gemfibrozil potentiates the action of coumadin and indanedione anticoagulants.
  • Lovastatin. Risk of myopathy when gemfibrozil is given to patients receiving lovastatin.

Read more at Wikipedia.org


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Advisory issued on repaglinide plus gemfibrozil: increased hypoglycemia risk.(Rx) : An article from: Internal Medicine News $5.95 Advisory issued on repaglinide plus gemfibrozil interaction: increased hypoglycemia risk.(Dermatologic Therapy) : An article from: Skin & Allergy News $5.95
Advisory issued on repaglinide + gemfibrozil use: increased hypoglycemia risk.(Rx) : An article from: Family Practice News $5.95

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