Gentamicin
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Gentamicin

Gentamicin is a aminoglycoside antibiotic, and can treat many different types of bacterial infections, particularly Gram-negative infection. more...

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Gentamicin works by binding to a site on the bacterial ribosome, causing the genetic code to be misread.

Like all aminoglycosides, gentamicin does not pass the gastro-intestinal tract, so it can only be given intravenously, intramuscularly or topically.

Gentamicin can cause deafness or a loss of equilibrioception in genetically susceptible individuals. These individuals have a normally harmless mutation in their DNA, that allows the gentamicin to affect their cells. The cells of the ear are particularly sensitive to this. It is sometimes used intentionally for this purpose in severe Ménière’s disease, to disable the vestibular apparatus.

Gentamicin can also be highly nephrotoxic, particularly if multiple doses accumulate over a course of treatment. For this reason gentamicin is usually dosed by body weight. Various formulae exist for calculating gentamicin dosage. Also serum levels of gentamicin are monitored during treatment.

E. Coli has shown some resistance to Gentamicin, despite being Gram-negative.

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Gentamicin-loaded sponges; multimodal rehabilitation; nocardial endophthalmitis; acute-onset endophthalmitis.(EVIDENCE FOR PRACTICE) : An article from: AORN Journal $5.95 Once daily high-dose gentamicin to prevent infection in open fractures of the tibia shaft: A preliminary investigation. (*).(Statistical Data Included) : An article from: Southern Medical Journal $5.95
Gentamicin resistance in biofilm producing pseudomonas aeruginosa causing catheter associated urinary tract infections.(Letter To Editor) : An article from: Indian Journal of Medical Sciences $5.95

Gentamicin-loaded sponges; multimodal rehabilitation; nocardial endophthalmitis; acute-onset endophthalmitis
Gentamicin-loaded sponges in infected total hip arthroplasty Acta Orthopaedica February 2005 Although prosthesis removal may be recommended for postoperative infection after total hip arthropla
Penetration of gentamicin into the alveolar lining fluid of critically ill patients with ventilator-associated pneumonia
Study objectives: To estimate the penetration of gentamicin into lung tissue by measuring its concentrations in alveolar lining fluid (ALF) and blood ...
Vitamin B12 prevents gentamicin-induced ototoxicity
Guinea pigs were given a single large dose of gentamicin (125 mg/kg intramuscularly), and were randomly assigned to receive methylcobalamin (a form of vitamin B12; 1 mg/kg intramuscularly), immedia
Sutureless circumcision; gentamicin-collagen implants; gentamicin prophylaxis; benefits of smoking cessation
Use of tissue glue in circumcision Pediatric Surgery International October 2004 Circumcision is a common surgical procedure that involves surgical ...
Bacterial survival in the interfacial gap in gentamicin-loaded acrylic bone cements
Clinical experience indicates the beneficial effects of antibiotic-loaded bone cement. Although in vitro studies have shown the formation of a biofilm ...
Gentamicin Sulfate 0.2%, Misoprostol 0.0024% and Phenytoin 5% Topical Gel
METHOD OF PREPARATION 1. Calculate the required quantity of each ingredient for the total amount to be prepared. 2. Accurately weigh and/or measure each ...
Gentamicin Sulfate, Neomycin Sulfate and Polymyxin B Sulfate Bladder Irrigation
METHOD OF PREPARATION Notes: This preparation should be done in a laminar airflow hood in a cleanroom or via isolation barrier technology by a validated ...
GENTAMICIN LEVELS IN DIAGNOSTIC ASPIRATES FROM PATIENTS WITH HIP AND KNEE ARTROPLASTY
Joint fluids obtained for diagnostic purposes from 25 patients were assayed for the presence of gentamicin. All of the patients had presented with failing ...

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