Chemical strucutre of α-D-glucosamine
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Glucosamine

Glucosamine (C6H14NO5) is a dietary supplement distributed as a salt — usually as glucosamine HCl, glucosamine sulfate potassium, or glucosamine sulfate sodium. A typical dosage is 1,500 mg per day. The salt complexes, glucosamine sulfate * KCl or glucosamine sulfate * NaCl, or the hydrochloride, glucosamine sulfate * HCl, are required for stabiliity. more...

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Glucosamine sulfate is a synthetic version of a compound the human body makes to stimulate the growth of cartilage. The idea is that such compounds help rebuild cartilage and reduce the symptoms of arthritis.

The supplement is an acceptable treatment in veterinary medicine, but the Arthritis Foundation and the American College of Rheumatology have not yet officially recommended it for humans, despite a large body of evidence supporting its use and the fact that it is considered a drug in several countries around the world. The United States Food and Drug Administration does not approve any dietary supplement, and, as such, at this time glucosamine is sold as a nutritional supplement and therefore does not need evidence of safety and efficacy. Glucosamine has been studied for over 20 years. As a natural substance that is already present inside the body, evidence bears out that glucosamine appears to be quite safe. One caveat - there is limited evidence that individuals with an allergy to shellfish should avoid glucosamine, as it is is usually derived from shellfish. There are vegetarian sources available.

Current research shows it may play a role in relieving pain associated with osteoarthritis. As used, it is often paired with MSM. The National Institutes of Health conducted a multi-arm, placebo-controlled study to see the effects of chondroitin and glucosamine on osteoporosis and osteoarthritis. Recent results of a 6-month clinical trial indicate that chondroitin sulfate (1.2 g) plus glucosamine (1.5 g) daily were as effective in relieving osteoarthritic knee pain as Celebrex, but more study would be helpful.

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Glucosamine
CLAIM Good for the joints, especially in active guys. LATEST FINDING Recent studies have shown that taking glucosamine can help slow or stop joint ...
Glucosamine: arthritis pain's natural foe just got more street credibility at the American College of Rheumatology's annual scientific meeting
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Is glucosamine effective for osteoarthritis of the knee?
Because of the publicity it has received in the media, glucosamine has become one of the most commonly used dietary supplements in the United States.
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I've heard that glucosamine is good for joint support. What is it and how does it work? Also, what type, and how much, should I take? --P.M., Cleveland, ...
Glucosamine: a review of its use in the management of osteoarthritis
Matheson AJ, Perry CM. Drugs Aging 2003;20:1041-1060. Glucosamine occurs naturally in all human tissues. It stimulates the synthesis of glycosaminoglycan, ...
The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled,
BACKGROUND: With increasing use of glucosamine-containing supplements for the treatment of osteoarthritis, there is increasing concern in the medical ...
Shellfish-free glucosamine - Nutra News You can use - Brief Article
Although millions of consumers use glucosamine as a dietary supplement to promote joint health, the fact that it is currently derived from shellfish complicates matters for those allergic to shellfi
Does glucosamine relieve arthritis joint pain? - Clinical inquiries: from the family practice inquiries network
EVIDENCE-BASED ANSWER Glucosamine may provide some pain relief. Studies have shown varied results, ranging from glucosamine being superior or equivalent ...

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