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Hereditary Multiple Exostoses

Hereditary Multiple Exostoses (HME) is a medical condition whereby multiple exostoses (bony spurs or lumps, also known as osteochondromas) develop on the bones of a child. Generally, when a person with HME reaches maturity, and their bones stop growing, the exostoses also stop growing.

It is estimated to occur in 1 person in 50,000. A person with HME is more likely to develop a form of bone cancer called chrondosarcoma as an adult.

It is an autosomal dominant disorder.

If necessary, the exostoses can be removed by surgery.

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A molecular characterization of the tricho-rhino-phalangeal syndromes (TRPS) and multiple hereditary exostoses (MHE) : (Dissertation) $55.00

Severity of disease and risk of malignant change in hereditary multiple exostoses: A GENOTYPE-PHENOTYPE STUDY
We performed a prospective genotype-phenotype study using molecular screening and clinical assessment to compare the severity of disease and the risk ...
Retardation of stature in hereditary multiple exostoses - a natural history
Introduction: Diminished adult stature is a key feature of Hereditary Multiple Exostoses (HME). Current debate on the pathogenesis of skeletal abnormalities ...
hip in hereditary multiple exostoses, The
We defined the characteristics of dysplasia and coxa valga in hereditary multiple exostoses (HME) by radiological analysis of 24 hips in 12 patients.
Acetabular dysplasia associated with hereditary multiple exostoses: A case report
Hereditary multiple exostoses is an autosomal dominant disorder characterised by multiple osteochondromata, most commonly affecting the forearm, knee ...
Chondrosarcoma in a family with multiple hereditary exostoses
Multiple hereditary exostoses is an autosomal dominant skeletal disorder in which there are numerous cartilage-capped excrescences in areas of actively ...
An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone
Osteochondroma is the most common benign bone tumour. The risk of sarcomatous change in an isolated lesion is approximately 1%. We report a case of an ...
Cervical myelopathy caused by an exostosis of the posterior arch of C1
We report a case of vertebral osteochondroma of C1 causing cord compression and myelopathy in a patient with hereditary multiple exostosis. We highlight ...
Corrections
Bobak P, Wroblewski BM, Siney PD, Fleming PA, Hall R. Charnley low-friction arthroplasty with an autograft of the femoral head for developmental dysplasia ...

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