Chemical structure of hydroxyzine.
Find information on thousands of medical conditions and prescription drugs.

Hydroxyzine

Hydroxyzine is a piperazine derivative that is used as an antihistamine (especially for itches), anti-emetic (nausea reducing), and anxiolytic (anxiety reducing) drug. It can also be used as an adjunct to pre- and post-operative medication and it also possesses a weak analgesic effect. Hydroxyzine is sold under brand names such as Atarax, Serecid and Vistaril. more...

Home
Diseases
Medicines
A
B
C
D
E
F
G
H
Habitrol
Halcion
Haldol
Haloperidol
Halothane
Heparin sodium
Hepsera
Herceptin
Heroin
Hetacillin
Hexachlorophene
Hexal Diclac
Hexal Ranitic
Hexetidine
Hibiclens
Histidine
Hivid
HMS
Hyalgan
Hyaluronidase
Hycodan
Hycomine
Hydralazine
Hydrochlorothiazide
Hydrocodone
Hydrocortisone
Hydromorphone
Hydromox
Hydroxycarbamide
Hydroxychloroquine
Hydroxystilbamidine
Hydroxyzine
Hyoscine
Hypaque
Hytrin
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Mode of action

Hydroxyzine is not a cortical depressant, but its effects on the central nervous system may be due to suppression of certain regions of the subcortical areas. The antihistamine effect is due to one of its metabolites cetirizine, which is a potent H1-antagonist.

Pharmacokinetics

Hydroxyzine can be administered orally as hydroxyzine hydrochloride or hydroxyzine embonate or as an intramuscular injection as hydroxyzine hydrochloride. When given orally, hydroxyzine is rapidly absorbed from the gastro-intestinal tract. The effect of hydroxyzine is notable in 30 minutes. Hydroxyzine is diffused throughout the body, but higher concentrations can be found in the skin than in the plasma. It is metabolised in the liver, and the main metabolite (45%), through oxidation of the alcohol moiety to a carboxylic acid, is cetirizine. Hydroxyzine's half-life is on average 14 hours for adults, but it can be as low as 5 hours for small children and over 30 hours for elderly people. Hydroxyzine is excreted into the urine almost wholly as metabolites.

Side effects

The side effects of hydroxyzine are usually mild, and include drowsiness and dry mouth, which is due to slight anticholinergic action. In rare cases muscle tremor and convulsions may occur.

Read more at Wikipedia.org


[List your site here Free!]


Medical thoracoscopy using a flexirigid thoracoscope in the diagnosis of pleural effusion of unknown cause
From CHEST, 10/1/05 by Atsuko Ishida

PURPOSE: To evaluate the efficacy of the flexirigid thoracoscope as a tool for the diagnosis in pleural effusions of unknown etiology.

METHODS: Between May 2002 and October 2004 19 patients with pleural effusion who had remained undiagnosed even after thoracentesis were performed medical thoracoscopy under local anesthesia using a flexirigid thoracoseope, a rigid thoracoscope with a bidirectional flexible tip. Patients were examined using supplemental oxygen, either in the endoscopy suite, or at the bedside in a general ward after premedicated with an intramuscular injection of hydroxyzine and pentazocine.

RESULTS: The mean age was 69 years, with a male/female ratio of 5:1. A definitive diagnosis was made in 17 of the 19 patients (89%), 6 malignant pleural mesothelioma, 5 metastatic pleural carcinoma, 4 tuberculous pleurisy, 1 empyema, and 1 uremic pleurisy. The mean examination time was 22 minutes. Complications observed were; 1 case of CO2 narcosis, 1 case of pneumothorax, and 5 cases of subcutaneous emphysema. There were no fatalities.

CONCLUSION: The flexirigid thoracoscopy under local anesthesia can be considered to be a rapid, easy, less invasive, and moreover an accurate diagnostic procedure.

CLINICAL IMPLICATIONS: It is expected to become a routine examination for pleural effusion of unknown etiology.

DISCLOSURE: Atsuko Ishida, None.

Atsuko Ishida MD * Teruomi Miyazawa MD Yuka Miyazu MD Yasuo Iwamoto MD Koji Kanoh MD Mika Zaima MD Takeo Inoue MD St. Marianna Univ. School of Medicine, Kawasaki, Japan

COPYRIGHT 2005 American College of Chest Physicians
COPYRIGHT 2005 Gale Group

Return to Hydroxyzine
Home Contact Resources Exchange Links ebay