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Inosine

Inosine is a molecule (known as a nucleoside) that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N₉-glycosidic bond. This is a very common modified nucleoside found in tRNAs and is essential for proper translation of the genetic code in Wobble base pairs. more...

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Inosine is a nucleic acid important for RNA editing. A (Adenine) is converted to I (Inosine), which pairs with G (Guanine).

Inosine is also an intermediate in a chain of purine nucleotides reactions required for muscle movements. It is currently being studied by Boston Life Sciences as a treatment for multiple sclerosis and stroke.

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	In vivo chromosome damaging effects of an inosine monophosphate dehydrogenase inhibitor: Ribavirin in mice Byline: K. Seetharama Rao, K. Narayana OBJECTIVE: To investigate the in vivo mutagenic effects of ribavirin in mice. METHODS: Mice were injected (i.p.) ... From Indian Journal of Pharmacology, 3/1/05 by K. Seetharama Rao

	Comparison of the Effect of Water Release on the Interaction of the Saccharomyces cerevisiae TATA Binding Protein (TBP) with "TATA Box" Sequences ABSTRACT The formation of sequence-specific complexes of TATA binding protein (TBP) with the minor groove of DNA results in the burial of large nonpolar ... From Biophysical Journal, 1/1/04 by Khrapunov, Sergei

	Literature Review & Commentary - glucosamine; obesity and sleep-disordered breathing; Procaine for itch treatment; inosine for multiple sclerosis; laughter Glucosamine hits the big time Two hundred-twelve patients with mild to moderate osteoarthritis of the knee were randomly assigned to receive, in double-blind ... From Townsend Letter for Doctors and Patients, 7/1/01 by Alan R. Gaby

	Molecular dynamics of DNA quadruplex molecules containing inosine, 6-thioguanine and 6-thiopurine ABSTRACT The ability of the four-stranded guanine (G)-DNA motif to incorporate nonstandard guanine analogue bases 6-oxopurine (inosine, I), 6-thioguanine ... From Biophysical Journal, 1/1/01 by Stefl, Richard

	MYCOPHENOLATE MOFETIL MAY PROTECT AGAINST Pneumocystis carinii PNEUMONIA IN RENAL TRANSPLANTED PATIENTS SUMMARY Pneumocystis carinii pneumonia (PCP) is usually prevented in transplanted patients by prophylactic trimethoprimsulfamethoxazol (TMS). Mycophenolate ... From Revista do Instituto de Medicina Tropical de Sao Paulo, 5/1/05 by Azevedo, Luiz Sergio

	Use of Helper Enzymes for ADP Removal in Infrared Spectroscopic Experiments: Application to Ca^sup 2+^-ATPase ABSTRACT Adenylate kinase (AdK) and apyrase were employed as helper enzymes to remove ADP in infrared spectroscopic experiments that study the sarcoplasmic ... From Biophysical Journal, 5/1/05 by Liu, Man

	Adenosine and the regulation of cerebral blood flow Objectives: This review summarizes the 30 year effort of my collaborator and mentor Dr J. W. Phillis to establish the role of adenosine in the regulation ... From Neurological Research, 3/1/05 by O'Regan, Michael

	Astrocytes and neurons: different roles in regulating adenosine levels Objectives: Adenosine is an endogenous nucleoside that signals through G-protein coupled receptors. Extracellular adenosine is required for receptor activation ... From Neurological Research, 3/1/05 by Parkinson, Fiona E

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