Cromoglicate chemical structure
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Intal

Cromoglicate (INN) (also referred to as cromolyn (USAN) or cromoglycate (former BAN)) is traditionally described as a mast cell stabilizing drug, and is commonly marketed as the sodium salt sodium cromoglicate. This drug prevents the release of chemicals such as histamine from mast cells. It is available as a nasal spray (Nasalcrom®) to treat allergic rhinitis, as an inhaler (Intal®) to treat asthma, as eye drops (Opticrom®) for allergic conjunctivitis, or in an oral form (Gastrocrom®) to treat mastocytosis). more...

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Although cromoglycate stabilizes mast cells, this mechanism is probably not why it works in asthma. Pharmaceutical companies have produced 20 related compounds that are equally or more potent at stabilising mast cells and none of them have shown any anti-asthmatic effect.

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A 40-year-old man with chronic generalized rash
From American Family Physician, 8/1/05 by Marianna L. Blyumin

A 40-year-old man presented with a 15-year history of recurrent generalized papules and macules. On examination, the physician noted multiple brown-red macules and flat-topped papules, 5 to 10 mm in diameter, on the patient's trunk and extremities (Figures 1 and 2). When these lesions were stroked, they became red, edematous, and pruritic, and some formed blisters.

[FIGURES 1-2 OMITTED]

Discussion

The answer is D: urticaria pigmentosa. Urticaria pigmentosa is the most common type of cutaneous mastocytosis. (1) Mastocytosis is a rare group of disorders resulting from the hyperplasia, infiltration, and accumulation of mast cells anywhere in the body. Urticaria pigmentosa may develop at any age; however, most cases affect children, often with initial manifestation at six to nine months of age. (2,3) There is no known predisposition by race or sex.

Clinically, urticaria pigmentosa exhibits disseminated multiple brown-red macules and papules (rarely nodules and plaques), most often on the trunk and extremities. Usually the palms, soles, face, and scalp are spared. (2) When the lesions are rubbed, they manifest erythema, edema, pruritus, and occasional bullae formation (i.e., Darier's sign). The blisters heal without scarring. (3) Patients often demonstrate prominent dermatographism and complain of generalized pruritus. (3)

The diagnosis is made clinically and confirmed with biopsy showing dermal infiltration by mast cells. Immunohistochemical stains may be used to detect mast cells. (4)

The course of the disease differs based on the age of the patient at onset. In the childhood form, about 10 percent of cases resolve and the majority significantly improve. The adult form usually is chronic and has a higher correlation with systemic involvement. (4,5)

The etiology of urticaria pigmentosa is unclear. However, it is known to be related to a mutation of c-kit, a proto-oncogene that encodes for KIT, the receptor for stem-cell factor that determines mast-cell differentiation and proliferation. (6)

Management entails treating cutaneous lesions and minimizing associated systemic symptoms. The results of treating skin lesions with topical steroids under occlusion and PUVA (psoralen plus ultraviolet A) vary. (5) To control associated systemic symptoms, histamine blockers ([H.sub.1] and [H.sub.2]), aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), cromolyn sodium (Intal), and ketotifen (Zaditor) ophthalmic solution often are used. (5) It also is crucial to emphasize avoidance of factors that trigger mast-cell degranulation (i.e., temperature and/or physical extremes, emotional stress, venoms, and certain medications [e.g., narcotics, salicylates, polymyxin sulfate, anticholinergics]). Patients at high risk for anaphylaxis should wear medical alert tags.

An adverse cutaneous drug reaction is a common immunologic response to medication. It often presents as a maculopapular or urticarial eruption within one to two weeks of starting the medication. Although this eruption may present clinically as generalized maculopapules, wheals, or both, the contrasting features include the recent onset and short-lived duration as well as the absence of pigmentation.

Acne vulgaris is an inflammatory disease of the pilosebaceous units that usually affects particular body regions (i.e., face, back, chest). It most often manifests in adolescents as comedones, papulopustules, and nodulocysts.

Syphilis presents in three stages. At the secondary stage, when the infection is systemic, it can mimic multiple cutaneous disorders. It usually is characterized by maculopapular, papulosquamous, pustular, or acneform eruptions that are prominent on the head, neck, palms, and soles.

Lymphocytoma cutis is a benign cutaneous inflammatory response to unknown stimuli. It usually presents in young adults as discrete nodules that may be pruritic or painful and are commonly localized to the face, chest, and upper extremities. Biopsy of the lesions demonstrates mixed inflammatory infiltrate. These lesions can be removed with excision or cryotherapy.

REFERENCES

(1.) Leaf FA, Jaecks EP, Rodriguez DR. Bullous urticaria pigmentosa. Cutis 1996;58:358-60.

(2.) Peretz E, Grunwald MH, Hallel-Halevy D, Halevy S. Brownish reticulate maculopapular eruption on the flexures. Arch Dermatol 2003;139:381-6.

(3.) Heide R, Tank B, Oranje AP. Mastocytosis in childhood. Pediatr Dermatol 2002;19:375-81.

(4.) Escribano L, Akin C, Castells M, Orfao A, Metcalfe DD. Mastocytosis: current concepts in diagnosis and treatment. Ann Hematol 2002;81:677-90.

(5.) Fenniche S, Marrak H, Zghal M, Khayat O, Debbiche A, Ben Ayed M, et al. Multiple nodular lesions of upper limbs: nodular mastocytosis. Dermatol Online J 2002;8:20-3.

(6.) Nagata H, Worobec AS, Oh CK, Chowdhury BA, Tannenbaum S, Suzuki Y, et al. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci U S A 1995;92:10560-4.

MARIANNA L. BLYUMIN, M.D.

Georgetown University Medical Center

Washington, DC

AMOR KHACHEMOUNE, M.D., C.W.S.

Harvard Medical School

Boston, MA

COPYRIGHT 2005 American Academy of Family Physicians
COPYRIGHT 2005 Gale Group

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