Find information on thousands of medical conditions and prescription drugs.

Interstitial cystitis

Interstitial cystitis (commonly abbreviated to "IC") is a urinary bladder disease of unknown cause characterised by pelvic and intense bladder pain, urinary frequency (as often as every 10 minutes), pain with sexual intercourse, and often pain with urination. It is not unusual for patients to experience nocturia and pain with sexual intercourse. IC is also known as painful bladder syndrome (PBS), particularly outside of the USA. more...

ICF syndrome
Ichthyosis vulgaris
Imperforate anus
Inborn error of metabolism
Incontinentia pigmenti
Infant respiratory...
Infantile spinal muscular...
Infective endocarditis
Inflammatory breast cancer
Inguinal hernia
Interstitial cystitis
Iodine deficiency
Irritable bowel syndrome

IC affects men and women of all cultures, socioeconomics and ages. Previously believed to be a condition of post menopausal women, growing numbers of men and women are being diagnosed in their twenties and younger. IC is not a rare condition. Recent research suggests that IC prevalence ranges from 1 in 100,000 to 5.1 in 1,000 of the general population. New epidemiological data for the United States should be released in 2006.

It is not unusual for patients to have beeen misdiagnosed with a variety of other conditions, including: overactive bladder, urethritis, urethral syndrome, trigonitis, prostatitis and other generic terms used to describe frequency/urgency symptoms in the urinary tract.


The cause of interstitial cystitis is unknown, though several theories have been put forward (these include autoimmune, neurologic, allergic and genetic). Regardless of the origin, it is clear that IC patients struggle with a damaged mucin, aka the GAG layer, aka bladdering lining. When this protective coating is damaged (perhaps via a UTI, excessive consumption of coffees or sodas, traumatic injury, etc.), urinary chemicals can "leak" into surrounding tissues causing pain, inflammation and urinary symptoms. Oral medications like Elmiron and medications which are placed directly into the bladder via a catheter work to repair and hopefully rebuild this damaged/wounded lining, allowing for a reduction in symptoms.

Recent work by the University of Maryland indicates that genetics are a factor in, and may even (in some cases) be the cause of IC. Two genes, FZD8 and PAND, are associated with the syndrome. FZD8, at gene map locus 10p11.2, is assocated with an antiproliferative factor secreted by the bladders of IC patients which "profoundly inhibits bladder cell proliferation," thus causing the missing bladder lining. PAND, at gene map locus 13q22-q32, is associated with a constellation of disorders (a "pleiotropic syndrome") including IC and other bladder and kidney problems, thyroid diseases, serious headaches/migraines, panic disorder, and mitral valve prolapse.


It may well be that the symptoms of interstitial cystitis have multiple causes, and IC is actually several syndromes which will eventually be discerned. For example, patients with Hunner's Ulcers are believed to be the most advanced cases. They have larger "wounds" in the bladder that are much more difficult to treat. It is estimated that only 5 to 10% of patients have these ulcers. Far more patients may experience a very mild form of IC, inwhich they have no visible wounds in their bladder, yet struggle with symptoms of frequency, urgency and/or pain. Still other patients may have discomfort only in their urethra, while others struggle with pain in the entire pelvis. Some patients may experience pelvic floor tightness and dysfunction, while others have normal muscle tone.


[List your site here Free!]

A Taste of the Good Life: A Cookbook for an Interstitial Cystitis Diet $22.53 Along the Healing Path : Recovering from Interstitial Cystitis $17.95
To Wake in Tears: Understanding Interstitial Cystitis $14.62 The Interstitial Cystitis Survival Guide: Your Guide to the Latest Treatment Options and Coping Strategies $9.37
Awakening Through the Tears: Interstitial Cystitis and the Mind/Body/Spirit Connection $14.29 Patient to Patient : Managing Interstitial Cystitis & Overlapping Conditions $19.99
The Patient's Encyclopaedia of Urinary Tract Infection, Sexual Cystitis and Interstitial Cystitis $22.17 Cystitis: A Time to Heal with Yoga & Accupressure, An Eight Week Exercise Program with Special Information on Interstitial Cystitis & Urethral Syndrome $13.51
Confident Choices: Customizing the Interstitial Cystitis Diet $14.44 Confident Choices: Customizing the Interstitial Cystitis Diet $20.00

Help for chronic interstitial cystitis
Dear Dr. SerVaas, I just read in the latest Saturday Evening Post about chronic interstitial cystitis and the excrutiating pain Mrs. Martin Zacha's ...
Interstitial cystitis: treating this painful condition naturally
Jan, a 67-year-old woman, came to me with the complaint of chronic urinary pain, which varied from mild to severe. The episodes lasted from days to weeks, and her symptoms returned periodically.
Interstitial cystitis: understanding the syndrome
Abstract Interstitial cystitis (IC) is a chronic pain syndrome that affects close to a million people in the United States. The syndrome presents differently in many individuals, with the unifyin
Diagnosis, Treatment, and Lifestyle Changes of Interstitial Cystitis - Statistical Data Included
Interstitial cystitis (IC) is a chronic inflammation of all the layers of the bladder wall. As it is difficult to diagnose and it affects mostly women, ...
Chronic pelvic pain? Think interstitial cystitis - Tips from Other Journals
Chronic pelvic pain affects up to 147 per 1,000 women. The etiology of the pain is frequently difficult to determine. Clemons and colleagues suspected ...
Interstitial Cystitis: Urgency and Frequency Syndrome
Interstitial cystitis is a chronic, severely debilitating disease of the urinary bladder. Excessive urgency and frequency of urination, suprapubic pain, ...
Interstitial Cystitis: A Bladder Problem - Brief Article
What is interstitial cystitis? Interstitial cystitis is a chronic bladder problem. About 750,000 Americans have interstitial cystitis. Most of them ...
Researchers Report Relief of IC Symptoms with Pentosan Polysulfate - interstitial cystitis
(96th Annual American Urological Association Meeting) The findings of the first study conducted to evaluate the onset of effect and dose-response relationship ...

Home Contact Resources Exchange Links ebay