Its main use is in colon cancer, particularly in combination with other chemotherapy agents. This includes the regimen FOLFIRI which consists of infusional 5-fluorouracil, leucovorin, and irinotecan.

Irinotecan is marketed by Pfizer as Camptosar. It is also known as CPT-11.

Side effects

Irinotecan is associated with severe diarrhea, sometimes leading to hospitalization for dehydration. This side effect is managed with the aggressive use of antidiarrheals such as loperamide or Lomotil with the first loose bowel movement.

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	Irinotecan label should include genotype data.(Gastroenterology) : An article from: Internal Medicine News $5.95	Gale Encyclopedia of Cancer : Irinotecan $2.30

	Selective serotonin reuptake inhibitor-induced rhabdomyolysis associated with irinotecan.(Case Report) : An article from: Southern Medical Journal $5.95


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