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Isoflurane

Isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether) is a halogenated ether used for inhalation anesthesia. Together with enflurane and halothane it replaced the flammable ethers used in the pioneer days of surgery. Its use in human medicine is now starting to decline, being replaced with sevoflurane, desflurane and the intravenous anaesthetic propofol. Isoflurane is still frequently used for veterinary anaesthesia. more...

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Isoflurane is always administered in conjunction with air and/or pure oxygen. Often nitrous oxide is also used. Although its physical properties means that anaesthesia can be induced more rapidly than with halothane, its pungency can irritate the respiratory system, negating this theoretical advantages conferred by its physical properties. It is usually used to maintain a state of general anesthesia that has been induced with another drug, such as thiopentone or propofol.

A major advantage of isoflurane is that it is no longer patented, and hence very economical to use.

It vaporizes readily, but is a liquid at room temperature. It is completely non-flammable.

Physical properties

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	A Comparison of Halothane and Isoflurane on Cerebral Ischemic Thresholds as Assessed by EEG and Cortical Depolarisation $31.00	Gender Effect on Recovery Time Following Isoflurane Administration While Using a Bispectral Index Monitor $25.95

	Liquid gastric emptying in the pig: Effect of concentration of inhaled isoflurane : An article from: The Journal of Nuclear Medicine $20.00


Changes in hemodynamics during isoflurane and propofol anesthesia: a comparison study Objectives: Volatile anesthetics are thought to impair cerebral autoregulation more than i.v. anesthetics. However, few comparative studies have been carried out in humans. The aim of our study was t From Neurological Research, 6/1/05 by De Cosmo, G

Isoflurane therapy for status asthmaticus in children and adults Two adults and two children with life-threatening asthma refractory to maximal standard therapy were treated with the inhalational anesthetic agent isoflurane. In each case, the temporal response t From CHEST, 3/1/90 by Richard G. Johnston

Influence of isoflurane anesthesia on motor evoked potentials elicited by transcortical, brainstem, and spinal root stimulation Electrical stimulation over the motor cortex, base of the skull, and cervical spine motor roots was performed in 9 male rats (410 86 g) before and after ... From Neurological Research, 9/1/98 by Haghighi, Siavash S

Lung-marginated Monocytes Modulate Pulmonary Microvascular Injury during Early Endotoxemia Rationale: The role of monocytes in acute endotoxemia has been ascribed to systemic release of mediators within the central circulation. Little is known ... From American Journal of Respiratory and Critical Care Medicine, 11/1/05 by O'Dea, Kieran P

Importance of early fluids resuscitation in murine sepsis: echocardiographic study PURPOSE: Fluid resuscitation and antibiotic administration are critical components of the early treatment of sepsis. We evaluated the impact of three ... From CHEST, 10/1/05 by Massimiliano Guglielmi

Pneumothorax-associated pleural eosinophilia in mice is interleukin-5 but not interleukin-13 dependent Study objectives: To establish a murine model of pneumothorax-associated pleural eosinophilia and to examine the role of interleukin (IL)-5 and IL-13 ... From CHEST, 10/1/05 by Ioannis Kalomenidis

The effect of thoracic epidural analgesia on the occurrence of late postoperative hypoxemia in patients undergoing elective coronary bypass surgery : a Study objectives: To evaluate the effect of perioperative thoracic epidural analgesia followed by postoperative epidural analgesia compared with conventional ... From CHEST, 9/1/05 by Lars Hyldborg Lundstrom

Intravenous immunoglobulin ameliorates experimental autoimmune encephalomyelitis and reduces neuropathological abnormalities when administered prophylactically Background and methods: Immunomodulation with intravenous immunoglobulin (IVIG) represents a way of interfering with the disease process in multiple sclerosis ... From Neurological Research, 9/1/05 by Jorgensen, Signe Humle

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