Lactulose chemical structure
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Lactulose

Lactulose (Generlac®, Cholac®, Constilac®, Enulose®, Acilac®) is a synthetic sugar used in the treatment of constipation and liver disease. It consists of the monosaccharides fructose and galactose. more...

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Constipation

In the treatment of chronic constipation, its metabolites draw water into the bowel, causing a cathartic effect through osmotic action.

Hepatic encephalopathy

In treating hepatic encephalopathy, lactulose helps "draw out" ammonia (NH3) from the body. The effectiveness of lactulose is somewhat controversial, and whether or not its effects are through ammonia is also controversial as well. Lactulose is metabolized in the colon by bacterial flora to short chain fatty acids, acidifying the colonic contents. This favors the formation of the nonabsorbable NH4+ from NH3, trapping NH3 in the colon and effectively reducing plasma NH3 concentrations.

Bowel Withholding

Lactulose can be used to treat children that withhold their bowel movements out of fear. The usual dosage is 1 tsp. for each year of the child's age, up to 30 ml. Mixed with juice, it is undetectable and works within four hours.

Side effects

Side effects include diarrhea and resultant dehydration and high sodium levels. In rare cases or with excess amounts can cause stomach pain, gas, vomiting, or diarrhea.

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Lactulose - A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References $39.36 Intestinal effects of mannanoligosaccharides, transgalactooligosacchari des, lactose and lactulose in dogs : An article from: The Journal of Nutrition $20.00
C-reactive protein and antibacterial activity in blood plasma of colostrum-fed calves and the effect of lactulose : An article from: Journal of Dairy Science $20.00

PEG 3350 vs. lactulose for constipation in children
Clinical Question: Is polyethylene glycol (PEG) 3350 or lactulose a better treatment for children with functional constipation? Setting: Outpatient ...
Effects of Prefeeding a Prebiotic on Diarrhea and Colonic Cell Proliferation in Piglets Fed Lactulose
ABSTRACT. Objectives: Severe lactulose malabsorption causes osmotic diarrhea and decreased cecal cell proliferation. We tested the hypothesis that prefeeding ...
Drugs, pregnancy, and lactation: GI agents: part I
Gastrointestinal complaints are common in pregnancy and the postpartum period. They include conditions such as nausea and vomiting, constipation, diarrhea, ...
Guideline for chronic constipation management
American College of Gastroenterology Chronic Constipation Task Force. An evidence-based approach to the management of chronic constipation in North America. Am J Gastroenterol 2005; 100:S1-S4. *
Management of chronic constipation: recommendations from a consensus panel
Chronic constipation (CC) results in more than 2.5 million visits to physicians and almost 100,000 hospitalizations in the United States annually? While ...
How should we evaluate and treat constipation in infants and children?
What are the indications for laboratory studies and imaging? * What dietary adjustments are most effective? * What medications are helpful? * When can enemas be used? * How effective is b
The secret garden: digestive health is built upon the existence of intestinal microflora that require sustenance from prebiotic ingredients. However, regardless
"In the antiseptic American culture, talking about healthy bacteria is an oxymoron," says Wendy Reinhardt Kapsak, MS, RD, director of health ...
Do probiotics reduce adult lactose intolerance? A systematic review - APPLIED EVIDENCE: New research findings that are changing clinical practice
Practice recommendations * Become familiar with the strains, concentrations, and preparations of probiotics most likely to be effective. * Because ...

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