vardenafil chemical structure
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Levitra

Vardenafil (Levitra) is a PDE5 inhibitor used in the treatment of erectile dysfunction. It can assist men with this disorder in achieving and maintaining an erection during sexual activity. more...

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As a PDE5 inhibitor, vardenafil is closely related in both function and marketing to sildenafil and tadalafil; it has a relatively short effective time, comparable to sildenafil.

History

Vardenafil was co-marketed by Bayer Pharmaceuticals and GlaxoSmithKline (GSK) under the trade name Levitra. As of 2005, the co-promotion rights of GSK on Levitra have been "transferred back" to Bayer in many markets outside of the United States. In Italy, Bayer markets the product as Levitra and GSK markets the product as Vivanza. Due to European Union trade rules, Parallel Imports made result in the Vivanza branded packs being seen alongside Levitra packs in pharmacies in other EU member states.

Clinical use

Main page: PDE5 inhibitor

Indications and contraindications are as for other PDE5 inhibitors.

Adverse drug reactions

More common adverse drug reactions (ADRs) are as per other PDE5 inhibitors and are listed on that page.

Common vardenafil-specific ADRs include: nausea. Infrequent ADRs include: abdominal pain, back pain, photosensitivity, abnormal vision, eye pain, facial oedema, hypertension, palpitation, tachycardia, arthralgia, myalgia, rash, itch, priapism. (Rossi, 2004)

Dose forms

It is available in 2.5 mg, 5 mg, 10 mg, and 20 mg doses in round orange tablets. The normal starting dose is 10 mg (roughly equivalent to 50 mg of sildenafil). Vardenafil should be taken 25-60 minutes prior to sexual activity, with a maximum dose frequency of once per day.

In some territories, such as the UK, only certain doses may be available, i.e. 5 mg, 10 mg, and 20 mg.

Reference

  • Rossi S (Ed.) (2004). Australian Medicines Handbook 2004. Adelaide: Australian Medicines Handbook. ISBN 0-9578521-4-2

Read more at Wikipedia.org


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Drugs cheaper in Canada except for Viagra, Cialis and Levitra
From Healthfacts, 11/1/05

To save money, Americans have been buying prescription drugs from Canada over the Internet for years. A team of Canadian researchers decided not only to test the perception that the same drugs purchased in Canada are, in fact, cheaper but they also set out to quantify the savings. Their findings, published recently in Annals of Internal Medicine, clearly favor shopping at the Canadian Internet pharmacies.

The researchers led by Bradley S. Quon, MD, compared prices at 12 Internet pharmacies in Canada with those at three major online drug chain pharmacies in the U.S. (CVS, Rite Aid, and Walgreen). The 44 brand-name drugs in this study are the medications Americans most often purchase from Canadian Internet pharmacies.

Quon and colleagues found that 41 of the 44 brandname drugs were less expensive in Canada, often substantially so. Only three drugs were more expensive in Canada--the erectile dysfunction drugs Viagra, Levitra, and Cialis. The biggest yearly savings applied to the antipsychotic drug, Zyprexa ($1,159), the diabetes drug, Actos ($852), and the heartburn drug, Nexium ($772).

Other drugs that were considerably less expensive in the Canadian Online pharmacies include the heartburn drugs Prevacid and Prilosec (sold under the brand name Losec in Canada); the antidepressants Celexa, Prozac, Wellbutrin, and Effexor; the antihistamine Zyrtec; and the cholesterol-lowering drugs Lipitor and Pravachol.

American law prohibits drug importation, but individuals are permitted to import up to 90 days worth of medications for personal use, according to Quon and colleagues. They note that Canadian pharmacies have taken advantage of this policy by selling up to a 90-day supply by mail order to Americans.

The Canadian Internet pharmacies were selected for this study on the basis of listings from Pharmacychecker.com. This Web site, Quon and colleagues identified as "a price comparison tool designed to assist consumers in obtaining their prescription medications at the lowest possible prices." The three American pharmacies were chosen because they are the largest drug stores based on sales revenue. (See next page for all Web addresses.)

Reminder:

In 2003, the Bush administration and its Congressional allies passed the Medicare Modernization Act. Despite the disingenuous name, this legislation forbids the federal government from negotiating discount prices for the drugs taken by people on Medicare. Canada--like most other industrialized nations --negotiates discounts with each pharmaceutical company.

COPYRIGHT 2005 Center for Medical Consumers, Inc.
COPYRIGHT 2005 Gale Group

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