vardenafil chemical structure
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Levitra

Vardenafil (Levitra) is a PDE5 inhibitor used in the treatment of erectile dysfunction. It can assist men with this disorder in achieving and maintaining an erection during sexual activity. more...

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As a PDE5 inhibitor, vardenafil is closely related in both function and marketing to sildenafil and tadalafil; it has a relatively short effective time, comparable to sildenafil.

History

Vardenafil was co-marketed by Bayer Pharmaceuticals and GlaxoSmithKline (GSK) under the trade name Levitra. As of 2005, the co-promotion rights of GSK on Levitra have been "transferred back" to Bayer in many markets outside of the United States. In Italy, Bayer markets the product as Levitra and GSK markets the product as Vivanza. Due to European Union trade rules, Parallel Imports made result in the Vivanza branded packs being seen alongside Levitra packs in pharmacies in other EU member states.

Clinical use

Main page: PDE5 inhibitor

Indications and contraindications are as for other PDE5 inhibitors.

Adverse drug reactions

More common adverse drug reactions (ADRs) are as per other PDE5 inhibitors and are listed on that page.

Common vardenafil-specific ADRs include: nausea. Infrequent ADRs include: abdominal pain, back pain, photosensitivity, abnormal vision, eye pain, facial oedema, hypertension, palpitation, tachycardia, arthralgia, myalgia, rash, itch, priapism. (Rossi, 2004)

Dose forms

It is available in 2.5 mg, 5 mg, 10 mg, and 20 mg doses in round orange tablets. The normal starting dose is 10 mg (roughly equivalent to 50 mg of sildenafil). Vardenafil should be taken 25-60 minutes prior to sexual activity, with a maximum dose frequency of once per day.

In some territories, such as the UK, only certain doses may be available, i.e. 5 mg, 10 mg, and 20 mg.

Reference

  • Rossi S (Ed.) (2004). Australian Medicines Handbook 2004. Adelaide: Australian Medicines Handbook. ISBN 0-9578521-4-2

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The big turnoff: stymied by politics and viagra, sex research goes limp
From Psychology Today, 1/1/05 by Justin Clark

IN THE SUMMER of 2003, a group of conservative members of Congress forced an audit of publicly funded sex studies, questioning the value of research derived from Asian prostitutes in San Francisco or everyday sexual risk-taking.

No legislation actually materialized from Congress--an amendment in the House of Representatives was defeated by two votes.

But a few months later, the Boston University Sexuality and Research Treatment Program quietly shut its doors. The National Institute of Mental Health had withdrawn funding, effectively closing down the 20-year-old program and its research into human sexual arousal.

Across the country, sex researchers are more worried about death than sex--that is, the slow demise of their own field. In the past year, conservative groups have pressured federal agencies to look long and hard at their spending plans. In a time of war and budget deficits, "these particular [National Institutes of Health] grants are simply not a wise use of taxpayer money," says Republican congressman Jeff Flake of Arizona.

Even the mere threat of funding cuts has had subversive effects, researchers say. It has, for example, forced many sex researchers to turn to drug companies for sponsorship. And that, according to Lenore Tiefer, professor of psychiatry at New York University, is ruining the sex lives of many Americans.

Sex researchers' dependence on pharmaceutical money, she says, has translated into a popular view that any sexual problem can be treated with a pill. As a consequence, sex research is drowning under "a tidal wave of reductionism, wherein sex is pelvic vascular function," says Tiefer. Drugs like Viagra, Cialis and Levitra are now the mass panacea for a flagging sex drive.

The critical questions of how emotions influence sexual feelings are no longer asked, researchers complain. They also say that whether the motive is political or financial, sex research has been diverted far from its original mission--deepening our understanding of this critical aspect of human behavior in a way that benefits all of society.

Sweeping the psychological side of sex under the rug in favor of the mechanical will ultimately hinder our understanding of the human condition, says Geoffrey Miller, an evolutionary psychologist and author of The Mating Mind. "If scientific funding agencies took on the goal of happiness as their responsibility, they would put sex research at the heart of the behavioral sciences."

Miller cites his own studies on kissing--why long-term couples often kiss less as the years go by and why people find kissing enjoyable in the first place--as examples of "a dark continent of research" that some would say is of questionable value. Studying the benefits of kissing could help couples rejuvenate a marriage and reduce divorce rates, says Miller, "but it's less threatening and more profitable to study orgasms."

What do conservative congressmen and others find so threatening? Childhood and adolescent sexuality, for starters. Few people want to acknowledge that children have sexual feelings, says Ohio State University psychologist Terri Fisher, yet adult sexual problems may have their origins in childhood. The issue is so taboo, she notes, that "we don't know how child sexuality bears on adult sexuality because no one has ever done a longitudinal study."

Another threat may be the suggestion that some sexual behavior considered undesirable--like infidelity--has deep roots in human nature. Miller's studies suggest that women's mate preferences vary during the menstrual cycle: At the peak of fertility women prefer handsome and creative men, but when fertility is low, they value men of social status and earning power. In other words, he says, women's divergent interests may lead them to cheat on a partner.

Pedophilia and sexual trauma are two topics unlikely to draw research funds from drug conglomerates or organizations under scrutiny in the current political climate. And yet these societal menaces could be better understood through the study of sexual arousal, "which we're on the verge of understanding," observes Janet Hyde, head of the psychology department at the University of Wisconsin.

Not all the objections to sexual research come from the political right. Feminists worry that any research that shows most sexual behavior is hardwired could be used to revive notions of females as a weaker or more irrational sex.

Ultimately, understanding the emotional and relational roots of sexuality is in society's best interests. It will provide a more direct route to satisfying relationships than drugs can, says University of New Brunswick researcher Sandra Byers. "Sexual satisfaction isn't just the absence of a problem, any more than happiness is the absence of depression."

COPYRIGHT 2005 Sussex Publishers, Inc.
COPYRIGHT 2005 Gale Group

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