Levothyroxine chemical structure
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Levoxyl


Levothyroxine, also known as L-thyroxine, synthetic T4 or simply 3,5,3',5'-tetraiodo-L-thyronine, is a synthetic form of thyroxine (thyroid hormone). As the hormone is chemically in the L-form (instead of D, see chirality), it is metabolised much slower than physiological thyroid hormone, which has a shorter half-life. more...

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The EU has recently standardised the use of the name "levothyroxine" for the drug. Common brand names include "Thyrax", "Euthyrox", "Levaxin" and "Eltroxin" in Europe, and "Levoxyl" and "Synthroid" in the US.

This medicine is usually given to patients with thyroid problems. These many problems can affect the patient's (if he/she is a child/teenager) growth and/or weight.

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Food intake cut bioavailability of rapid-release Levoxyl by 40%
From OB/GYN News, 12/15/04 by Bruce Jancin

VANCOUVER, B.C. -- Bioavailability of even the newer rapid-release formulation of levothyroxine known as Levoxyl is reduced 40% by taking the tablets close to a meal. Michael J. Lamson, Ph.D., said at the annual meeting of the American Thyroid Association.

The hope had been that Levoxyl's rapid release might permit a new flexibility in dosing, allowing patients to take the drug in proximity to meals instead of on an empty stomach, as has traditionally been recommended for L-T4 therapy. But that didn't prove to be the case in the first large study to assess the effects of a meal on oral absorption of L-T4 using the Food and Drug Administration's formal bioequivalence methodology, explained Dr. Lamson of King Pharmaceuticals.

He reported on 48 healthy participants in a randomized, three-way crossover trial. They took two 300-mcg tablets of Levoxyl on three occasions, each separated by a 35-day washout. One dose was taken under fasting conditions. The second dose was taken 10 minutes before consuming what is known in the world of pharmacokinetics research as a "standard FDA breakfast"--a 950-kcal, 58% fat meal consisting of eggs, bacon, hash browns, toast, and milk. The third dose was taken immediately after consuming such a breakfast.

Bioavailability of L-T4 was reduced by 40% regardless of whether subjects took the drug shortly before or immediately after the meal. This is a clinically significant finding, because it is well established that even small changes in L-T4 bioavailability can have a profound impact upon the success of oral replacement therapy.

In clinical terms, this means that taking rapid-release L-T4 in proximity to a meal or a medication known to interfere with L-T4 renders a 100-mcg dose of Levoxyl equivalent to a 60-mcg dose. Dr. Lamson said.

COPYRIGHT 2004 International Medical News Group
COPYRIGHT 2005 Gale Group

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