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Lotronex

Alosetron is a 5-HT₃ antagonist used for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women only. It was withdrawn from the market in 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, but was reintroduced in 2002 with availability and use restricted. It is currently marketed by GlaxoSmithKline under the trade name Lotronex. more...

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Mode of action

Alosetron, while being a 5-HT₃ antagonist like ondansetron, is not an antiemetic. Alosetron has an antagonist action on the 5-HT₃ receptors of the enteric nervous system of the gastrointestinal tract.

Serious adverse effects

Alosetron was withdrawn in 2000 following the association of alosetron with serious life-threatening gastrointestinal adverse effects.

The cumulative incidence of ischaemic colitis was 2 in 1000, while serious complications arising from constipation (obstruction, perforation, impaction, toxic megacolon, secondary colonic ischaemia, death) was 1 in 1000 (GlaxoSmithKline, 2002).

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	Drug for severe IBS will be reintroduced in risk program. (Restrictions in Place for Lotronex).(irritable bowel syndrome) : An article from: Family Practice News $5.95	RXNews: Why I voted against lifting the ban on Lotronex : An article from: HealthFacts $10.00

	Lotronex - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References $24.95


FDA advisory panel hearing: managing risk of IBS drug Lotronex ROCKVILLE, MD. -- Several members of a Food and Drug Administration advisory panel agreed that the risk management program in place for the irritable ... From OB/GYN News, 6/1/04 by Elizabeth Mechcatie

Return of Lotronex? - Brand Watch - FDA plans advisory committee Return of Lotronex? (Brand Watch).(FDA plans advisory committee) From Drug Store News, 2/18/02 by James Frederick

FDA approval of alosetron re-introduction - Lotronex - Brief Article The U.S. Food and Drug Administration (FDA) approved the re-introduction of alosetron hydrochloride (Lotronex) under restricted conditions of use. According to the manufacturer, alosetron will be From American Family Physician, 8/1/02 by Brian Torrey

FDA approves restricted marketing of Lotronex - Updates The FDA has approved the marketing of Lotronex (alosetron hydrochloride) with restrictions, nearly two years after its manufacturer removed it from the market. Lotronex is the only medication prove From FDA Consumer, 7/1/02

Why I Voted Against Lifting The Ban On Lotronex - Brief Article A drug, banned two years ago because it caused death and severe injury, is about to make a comeback. A Food and Drug Administration advisory committee ... From Healthfacts, 6/1/02 by Arthur A. Levin

Lotronex In March 2000, Lotronex, a drug for irritable bowel syndrome (IBS) developed by Glaxo, went on the market and was expected to reach sales of $1 billion ... From Townsend Letter for Doctors and Patients, 6/1/01 by Jule Klotter

Lotronex removed from the market Glaxo Wellcome withdrew alosetron hydrochloride (Lotronex), a prescription drug for treating women who have irritable bowel syndrome (IBS), from the market ... From Nursing, 1/1/01

Drug for irritable bowel syndrome taken off the market - Lotronex - News Alosetron hydrochloride (Lotronex), a prescription drag manufactured by GlaxoWellcome, and used to treat irritable bowel syndrome in women, has been ... From British Medical Journal, 12/9/00 by Fred Charatan

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