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Lovastatin

Lovastatin is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease (hypolipidemic agents). The mode of action of statins is HMG-CoA reductase enzyme inhibition. more...

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Lovastatin was isolated from a strain of Aspergillus terreus and it was the first statin approved by the FDA (August 1987).

Lovastatin is also naturally produced by certain higher fungii such as Pleurotus ostreatus (oyster mushroom) and closely related Pleurotus spp. (Bobek et al., 1998)

In 1998, the US FDA placed a ban on the sale of dietary supplements derived from red yeast rice, which naturally contains lovastatin, arguing that products containing prescription agents require drug approval.

Brand names

Mevacor®
Advicor® (as a combination with niacin)
Altocor®
Altoprev®

Reference

Bobek P, Ozdin L, Galbavy S. Dose- and time-dependent hypocholesterolemic effect of oyster mushroom (Pleurotus ostreatus) in rats. Nutrition 1998;14:282-6. PMID 9583372.

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	Cholesterol-lowering diet vs. treatment with lovastatin - Tips from Other Journals Efforts to lower cholesterol through dietary manipulations have had only modest effects. In an attempt to increase the efficacy of diet in the prevention ... From American Family Physician, 2/1/04 by Caroline Wellbery

	Effect of Niacin Extended Release and Lovastatin tablets on walking in patients with intermittent claudication - Clinical Trial Review Sponsored by: Kos Pharmaceuticals Purpose: You are being asked to participate in a research study that will determine if Niacin ER/Lovastatin at two ... From Journal of Drugs in Dermatology, 8/1/03

	Andrx Corporation is offering a prescription drug assistance program for Altocor extended release tablets for cholesterol therapy - lovastatin - Drug Andrx Corporation is offering a prescription drug assistance program for Altocor (lovastatin) extended release tablets for cholesterol therapy. The ... From Drug Cost Management Report, 7/11/03

	Lovastatin in Adolescents with Familial Hypercholesterolemia The age at which lipid-lowering drug therapy should be started in patients with familial hypercholesterolemia and premature coronary disease is not well defined, although there is agreement that dr From American Family Physician, 5/15/99 by Grace Brooke Huffman

	Statins for Algernon: cholesterol-lowering drug fights learning disability In Daniel Keyes' 1966 novel Flowers for Algernon (Harcourt), an experimental treatment gives a mouse and a learning-disabled man increased intellectual ... From Science News, 11/12/05 by Christen Brownlee

	Use of lovastatin in blacks with hypercholesterolemia - Tips from Other Journals Black patients have almost twice the age-adjusted risk of dying from coronary heart disease as do white patients. Lipid-lowering drugs are known to have ... From American Family Physician, 1/15/98 by Grace Brooke Huffman

	Effect of lovastatin on quality of life in elderly patients - Tips from Other Journals Hypercholesterolemia is known to be associated with a higher risk of coronary events. Although some data exist regarding the efficacy of lipid-lowering ... From American Family Physician, 8/1/97 by Grace Brooke Huffman

	Relative effectiveness of niacin and lovastatin for treatment of dyslipidemias in a health maintenance organization BACKGROUND. We conducted an historical cohort study to evaluate the relative effectiveness of niacin and lovastatin in the treatment of dyslipidemias in patients enrolled in a health maintenance orga From Journal of Family Practice, 5/1/97 by Patrick J. O'Connor

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