Meleda Disease
Meleda disease is an extremely rare, inherited skin disorder in which dry, thick patches of skin develop on the soles of the hands and feet, a condition known as palmoplantar hyperkeratosis.
It is most common on the Dalmatian island of Meleda, thought to be because of a founder affect. It is of autosomal recessive inheritance. It may be caused by a mutation on the SLURP1 gene at chromosome 8qter.
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Mac Ardle disease
