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Myelofibrosis

Myelofibrosis, one of the myeloproliferative diseases, is the gradual replacement of the bone marrow by connective tissue. Its main feature is "extramedullary hematopoeisis", i.e. the blood-forming cells migrate to other sites in the body, e.g. the liver or spleen. Typically affects patients > 50 years. Patients will typically have hepatosplenomegaly, and the blood smear will show "teardrop cells".


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Myelofibrosis Myelofibrosis is a rare blood disorder of people over the age of 50. From Gale Encyclopedia of Medicine, 4/6/01 by J. Ricker Polsdorfer

Acute Lymphoblastic Leukemic Transformation in a Patient With Chronic Idiopathic Myelofibrosis and Paroxysmal Nocturnal Hemoglobinuria: A case Report and Leukemic transformation of chronic idiopathic myelofibrosis (CIMF) to acute lymphoblastic leukemia (ALL) is rare. We report a case of a patient with CIMF ... From Archives of Pathology & Laboratory Medicine, 1/1/05 by Shaheen, Saad Paul II

Histiocytic Sarcoma Associated With Idiopathic Myelofibrosis We describe the case of a 39-year-old man with idiopathic myelofibrosis, who developed histiocytic sarcoma (true histiocytic lymphoma) 6 months after diagnosis. The patient developed generalized lymp From Archives of Pathology & Laboratory Medicine, 10/1/04 by Fukunaga, Masaharu

Myelofibrosis Definition Myelofibrosis is a rare disease of the bone marrow in which collagen builds up fibrous scar tissue inside the marrow cavity. This is ... From Gale Encyclopedia of Cancer, by M.D. J. Ricker Polsdorfer

Evaluation of Stroma in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome-Affected Bone Marrows and Correlation With CD4 Counts Context.-Little is known about cellular and extracellular composition of fibrosis in bone marrows in the context of human immunodeficiency virus/acquired ... From Archives of Pathology & Laboratory Medicine, 9/1/05 by O'Malley, Dennis P

REVLIMID® Clinical Results as Oral Treatment Regimen in Myelofibrosis Presented at the 47th American Society of Hematology Meeting ATLANTA, Dec. 13 /PRNewswire-FirstCall/ -- Celgene Corporation announced that clinical data from a REVLIMID (lenalidomide) study in myelofibrosis (MF) were reported at an oral presentation during From PR Newswire, 12/13/05

Splenectomy Splenectomy is the surgical removal of the spleen, which is an organ that is part of the lymphatic system. The spleen is a dark-purple, bean-shaped organ ... From Gale Encyclopedia of Medicine, 4/6/01 by Teresa G. Norris

Bone marrow aspiration and biopsy Bone marrow aspiration, which is also called bone marrow sampling, is the removal by suction of fluid from the soft, spongy material that lines the inside ... From Gale Encyclopedia of Medicine, 4/6/01 by Maureen Haggerty

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Myelofibrosis

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