Ropivacaine (1-propyl-2’,6’-pipecoloxylidide; Naropin®) is a long-acting local anesthetic given by injection to reduce the sensation of pain. It is often used in pregnant women during labor, particularly for epidural anesthesia. It is also used peripherally and in nerve blocks.
Ropivacaine was developed after bupivacaine was noted to be associated with cardiac arrest in 0.5-0.75% of cases, particularly in pregnant women. Ropivacaine, a pure S-enantiomer, was found to have less cardiotoxicity in animal models.