Nialamide

Nialamide was one of the first MAOI (monoamine oxidase inhibitor) antidepressants. It is chemically related to iproniazide, another MAOI derived from isonicotinic acid. more...

Uses

Approved

Nialamide is effective for depression characterized by anergic symptoms, endogenous depression, and reactive depression.

Unapproved/Off-Label/Investigational

Nialamide is sometimes used in the treatment of trigeminal neuralgia. It has also been studied for alcoholism, dermatomally distributed vitiligo, irregular menstrual cycle,, angina, cerebrovascular disorders, and the prevention of streptomycin-induced deafness.

Side Effects

Side effects of nialamide include insomnia, vertigo, hyperhidrosis, weight gain, vomiting, tachycardia, constipation, dry mouth, upset stomach, orthostatic hypotension and decreased systolic pressure.

Tradenames

Nialamide is sold under Psicodisten®, Niaquitil®, Nialamid®, Niamidal®, Niamide®, Novazid®, Nuredal®, Niamid® (Italy, Belgium, Netherlands, England, United States), Niazin®, Nyazin®, Surgex® (Italy), Mygal®, Delmoneurina®, Isalizina® (Italy), Espril® (Italy), and Nyezin®.

References and End Notes

1. ^  SID 35970 -- PubChem Substance Summary. URL accessed on 27 August 2005. National Center for Biotechnology Information.
2. ^  see SID 35970 -- PubChem Substance Summary, 2005.
3. ^  see SID 35970 -- PubChem Substance Summary, 2005.
4. ^  see BIAM, 2001.
5. ^  Benady DR, Clein LJ, Pare CM (1965). Intramuscular nialamide in intractable depression. Diseases of the Nervous System 26 (12): 792-4. PMID 5321917 List of Print Collections
6. ^  Oules J, Cabazon (1964). . Toulouse Medical 65 (1): 1298-302. PMID 14272189. New York Academy of Medicine Library holding
7. ^  Vaisberg M, McGahee CL, Radinger N, Saunders JC (1959). Nialamide for the treatment of anergy and depression. Diseases of the Nervous System 20 (Supplemental): 22-5. PMID 13840714. List of Library Holdings
8. ^  Van Reeth PC, Bloch C (1960). . Acta Neurologica Belgica 60 (1): 320-7. PMID 13841128 Harvard University Library Holding
9. ^  Cormary M (1966). . Lyon Medical 215 (15): 1051-62. PMID 5930244 List of Library Holdings
10. ^  Bobrov AE, Shurygin AN, Krasil'nikov SB (1991). . Zhurnal Nevropatologii i Psikhiatrii Imeni SS Korsakova. 91 (2): 79-83. PMID 1647635 List of Library Holdings
11. ^  Koga M (1977). Vitiligo: a new classification and therapy. British Journal of Dermatology 97 (3): 255-61. PMID 921895. List of Library Holdings
12. ^  Gautray JP, Jolivet A (1976). . Annales d'Endocrinologie 37 (4): 293-4. PMID 1022189. List of Library Holdings
13. ^  Barats SS, Oranskii IE, Kartashova DI, Gorovater EN (1976). . Kardiologiia 16 (3): 138-40. No absract. PMID 1021625 List of Library Holdings
14. ^  Mirzoian RS (1975). . Biulleten' Eksperimental'noi Biologii i Meditsiny 80 (11): 50-3. PMID 1218262 List of Library Holdings
15. ^  Semczuk B, Klonowski S, Golabek W (1974). The protective effect of niamid on hearing in patients treated with large doses of streptomycin. Annales Universitatis Mariae Curie-Sklodowska Sectio D: Medicina 29 (1): 193-7. No abstract. PMID 4467804 List of Library Holdings
16. ^  Anonymous. NIALAMIDE. Antidepresseurs. BIAM. URL accessed on 27 August 2005.
17. ^  see BIAM, 2001.
18. ^  see BIAM, 2001.
19. ^  see BIAM, 2001.
20. ^  SID 35970 -- PubChem Substance Summary - Depositor-Supplied Synonyms: All. URL accessed on 25 September 2005. National Center for Biotechnology Information.

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