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Nitrofurantoin

Nitrofurantoin (trade names Furadantin, Macrobid, Microdantina, and Macrodantinis) is an antibiotic drug. While it can fight a wide variety of infections, it is commonly used to fight urinary tract infections. The drug is considered reasonably safe during pregnancy by the FDA. The drug works by damaging bacterial DNA, since its reduced form is highly reactive. This is made possible by the rapid reduction of nitrofurantoin inside the bacterial cell. more...

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Side Effects

Nitrofurantoin can cause nausea and vomiting, fever, rash, hypersensitivity pneumonitis, and progressive pulmonary interstitial fibrosis. All these side effects are much more common in the elderly. Additionally, nitrofurantoin changes urine into a dark orange-brown color, and patients should be made aware of this so they are not alarmed.

Precautions

Nitrofurantoin must be taken with food and can cause bleeding in the stomach, vomiting and other gastrointestinal disruptions if these warnings are not adhered to.

Reference

  • drugs.com for Macrodantin
  • Nitrofurantoin Side Effects, Interactions and Information

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Nosocomial urinary tract infection due to Leuconostoc mesenteroides at a tertiary care centre in north India
From Indian Journal of Medical Research, 8/1/05 by Taneja, Neelam

Sir,

Leuconostoc are catalase-negative Gram-positive cocci which are often misidentified as lactobacilli, streptococci, pediococci or enterococci as all these genera share several biochemical properties. The Leuconostoc are intrinsically resistant to vancomycin. These organisms were earlier considered to be nonpathogens before 1985'. Though uncommonly isolated, these organisms have now gained importance as opportunistic pathogens. The reported human infections include bacteraemias2, meningitis3, breast abscess4, peritonitis5 and abdominal abscess6. In late 1990s, these organisms have been implicated in causing a small outbreak of nosocomial urinary tract infection (UTI)1. However, there are no such reports of Leuconostoc infections from India. In the present communication, we report an outbreak of nosocomial UTI caused by these organisms in a tertiary care centre in north India.

Leuconostoc isolates were recovered in pure culture, in significant numbers (>105 cfu/ml) from 12 patients admitted to the Postgraudate Institute of Medical Education & Research (PGIMER), Chandigarh, during October 2000 and April 2001. A total of 9664 urine samples were cultured on cysteine lactose electrolyte deficient medium (CLED) during the period. Leuconostoc were incidentally found while characterizing all the significant catalsase-negative Gram-positive cocci. The organisms were identified by using a battery of biochemical tests according to the conventional scheme of Facklam et al1. Vancomycin susceptibility was tested by disc diffusion8 using 30 µg disc and vancomycin resistance was confirmed by E-test (AB Biodisk, Solna, Sweden). All the isolates were catalase-negative, pyrrolidonyl arylamidase (PYR; Sigma St. Louise, Mo) - negative, resistant to vancomycin, and did not grow at 45°C. All could grow in presence of 6.5 per cent NaCl and at 10°C. All produced acid in sucrose, maltose, raffinose, arabinose, mellibiose, mannitol and trehalose. Six of the 12 were lactose-positive and all were xylose-negative. None of the isolates deaminated arginine. These organisms were identified as Leuconostoc mesenteroides and were confirmed by using the BD-BBL crystal identification systems (Gram-Positive ID Kit-Sparks, Maryland, USA). Antimicrobial susceptibility was performed for amoxycillin (30 µg), penicillin (10 µl), nitrofurantoin (300 µg) and piperacillin (100 µg) by Kirby-Bauer method8 using Enterococcus fecalis ATCC 29212 as control and using antibiotic disks from Hi-Media Laboratories, Mumbai. Three of the 12 isolates were resistant to penicillin and amoxycillin, two were resistant to nitrofurantoin and one to piperacillin. Four isolates were intermediately susceptible to penicillin and one each was intermediately susceptible to nitrofurantoin and piperacillin. The clinical details of the patients were noted from the hospital records and were available for only 8 patients (5 females and 3 males). The age ranged from 2 months to 65 yr. All females were admitted in Obstetrics and Gynaecological unit. Three developed symptomatic nosocomial UTI, two of them underwent surgery for removal of fibroid and ovarian tumour and suffered from catheter related nosocomial UTI. In the other two females there, were no symptoms related to UTI and therefore the organisms were considered as contaminants. Among the three male patients who had nosocomial UTI, one had malignancy of urinary bladder and another had stricture urethra. The third patient was a two-month old child with exstrophy bladder. All three developed symptomatic nosocomial UTI. All symptomatic patients responded to antibiotics and removal of urinary catheter (catheter was put in 3 patients). None of the patients developed features of clinical sepsis. Clustering of the cases was seen in three female patients from Gynecology ward. As these organisms are intrinsically resistant to vancomycin, infections occur more frequently in patients being treated for underlying diseases with vancomycin therapy8. None of the patients in the present study had received vancomycin. Though these organisms may also be found as normal flora of alimentary tract, data supporting this contention are lacking10. Handwerger and colleageues11 observed that neonates had a predisposition to develop bacteraemia suggesting that during delivery infants might become colonized with Leuconostoc inhabiting the maternal genital tract. In our patients the precise mode of transmission could not be known, though in another study where faecal samples were screened for vancomycin-resistant enterococci (VRE), we found many vancomycinresistant Gram-positive cocci were actually Leuconostoc (unpublished data). Nosocomial transmission might have occurred through contaminated hands or fomites or the organisms might have entered at the time of urinary catheterization or instrumentation.

In summary, though uncommonly isolated these organisms can cause nosocomial UTI and have potential for causing outbreak. These are likely to be misidentified as enterococci in routine microbiology laboratory. Enterococci can also be vancomycinresistant but are PYR-positive. PYR test negativity can be used as an important method to differentiate Leuconostoc spp. from VRE.

References

1. Cappelli EA, Barros RR, Camello TC, Teixeira LM, Merquior VL. Leuconostoc pseudomesenteroides as a cause of nosocomial urinary tract infections. J Clin Microbiol 1999; 37 : 4124-6.

2. Barreau C, Wagener G. Characterization of Leuconostoc lactis strains from human sources. J Clin Microbiol 1990; 28: 1728-33.

3. Friedland IR, Snipelisky M, Khoosal M. Meningitis in a neonate caused by Leuconostoc sp. J Clin Microbiol 1990; 25:2125-6.

4. Barry H, Clancy MT, Brady A, O'Higgins N. Isolation of a Leuconostoc species from a retroareolar breast abscess. J Infect 1993; 27 : 208-10.

5. Templin KS, Crook T, Riley T 3rd, Whitener C, Aber RC. Spontaneous bacterial peritonitis and bacteremia due to Leuconostoc species in a patient with end-stage liver disease: a case report. J Infect 2001; 43 : 155-7.

6. Montejo M, Grande C, Valdivieso A, Testillano M, Minguillan J, Aguirrebengoa K, et al. Abdominal abscess due to Leuconostoc species in a liver transplant recipient. J Infect 2000; 41 : 197-8.

7. Facklam R, Hollis D, Collins MD. Identification of Grampositive coccal and cocobacillary vancomycin-resistant bacteria. J Clin Microbiol 1989; 27 : 724-30.

8. Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol 1966; 45 : 493-6.

9. Horowitz HW, Handwerger S, van Horn KG, Wormser GP. Leuconostoc, an emerging vancomycin-resistant pathogen. Lancet 1987; ii : 1329-30.

10. Ruoff KL. Leuconostoc, pediococcus Stomatococcus and miscellaneous Gram-positive cocci that grow aerobically. In: Murray PR, Baron EJ, Piaffer MA, Tenover FC, Yolken RH, editors. Manual of clinical microbiology, 7th ed. Washington DC: ASM Press; 1999 p. 306-15.

11. Handwerger S, Horowitz H, Coburn K, Kolokathis A, Wormser GP. Infections due to Leuconostoc species: six cases review. Rev Infect Dis 1990; 12 : 602-10.

Neelam Taneja+, Phulan Rani, Rekha Emmanuel, Bassam Yasein Khudaier**, Surinder Kumar Sharma*, Rupinder Tewari** & Meera Sharma

Departments of Medical Microbiology,

* Urology, Postgraduate Institute of Medical Education & Reseach,

** Department of Biotechnology,

Panjab University, Chandigarh 160012, India

+ For correspondence:

e-mail: drneelampgi@yahoo.com

Copyright Indian Council of Medical Research Aug 2005
Provided by ProQuest Information and Learning Company. All rights Reserved

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