Oxazepam chemical structure
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Oxazepam

Oxazepam (marketed under brand names Alepam®, Murelax®, Serax®, Serepax®, Seresta®) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. more...

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Pharmacology

See Diazepam#Pharmacology. Oxazepam is also a metabolic by-product of diazepam.

Indications

It is an intermediate acting benzodiazepine with a slow onset of action, so it is usually prescribed to individuals who have trouble staying asleep, rather than falling asleep. It is commonly prescribed for anxiety disorders with associated tension, irritability, and agitation. It is also prescribed for drug and alcohol withdrawal, and for anxiety associated with depression.

Dosage

  • Mild/moderate anxiety - 10 to 15mg, 3 to 4 times daily
  • Severe anxiety - 15 to 30mg, 3 to 4 times daily
  • Symptoms related to alcohol withdrawl - 15 to 30mg, 3 to 4 times daily

Side Effects

See Diazepam#Side_Effects.

Interactions

See Diazepam#Interactions.

Contraindications

See Diazepam#Contraindications.

Overdose

See Diazepam#Overdose.

Legal Status

Oxazepam is a Schedule IV drug under the Convention on Psychotropic Substances .

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Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam - Abstract
From Alternative Medicine Review, 12/1/01

Objective: Passionflower (Passiflora incarnata) is a folk remedy for anxiety. A double-blind randomized trial compared the efficacy of Passiflora incarnata extract with oxazepam in the-treatment of generalized anxiety disorder. Methods: The study was performed on 36 out-patients diagnosed with GAD using DSM IV criteria. Patients were allocated in a random fashion: 18 to the Passiflora extract 45 drops/day plus placebo tablet group, and 18 to oxazepam 30 mg/day plus placebo drops for a 4-week trial. Results: Passiflora extract and oxazepam were effective in the treatment of generalized anxiety disorder. No significant difference was observed between the two protocols at the end of trial. Oxazepam showed a rapid onset of action. On the other hand, significantly more problems relating to impairment of job performance were encountered with subjects on oxazepam. Conclusion: The results suggest that Passiflora extract is an effective drug for the management of generalized anxiety disorder, and the low incidence of impairment of job performance with Passiflora extract compared to oxazepam is an advantage. A large-scale trial is justified.

Akhondzadeh S, Naghavi HR, Vazirian M, et al. J Clin Pharm Ther 2001;26:363-367.

COPYRIGHT 2001 Thorne Research Inc.
COPYRIGHT 2002 Gale Group

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