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Oxymetholone

Oxymetholone (Anadrol), is a synthetic anabolic steroid developed by Syntex in 1960. Its primary clinical applications include treatment of osteoporosis and anaemia, as well as stimulating muscle growth in undernourished or underdeveloped patients. The drug was approved for human use by the FDA. However, later non-steroidal drugs such as Epogen were developed and proven to be more effective as a treatment for anaemia and osteoporosis without the side-effects of oxymtholone. more...

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The drug remained available despite this, and eventually found a new use in treating HIV wasting syndrome. While classified as a Schedule III drug under the Controlled Substances Act, it remains available via prescription as Anadrol (registered as a trademark of Unimed Pharmaceuticals.)

Presented most commonly as a 50mg tablet, Oxymetholone is the strongest androgenic steroid available. Similarly, it also poses the greatest risk of side effects of any steroid. Despite very low binding affinity with the androgen receptor, oxymetholone is highly effective in promoting extensive gains in body mass, mostly by greatly improving muscular water retention. For this reason, it is often used illegally by bodybuilders and athletes. Many athletes also use Oxymetholone as a method of protection for the joints under heavy loads. Due to the high water retention users experience from this drug, it similarily lubricates the joints and helps protect them from injury.

Side effects

The side-effects of short-term use of the drug itself include nausea, bloating, acne, and masculinising effects such as deepening of the voice, growth of facial hair and clitoral hypertrophy . In addition, oxymetholone is readily aromatized by aromatase to form a progestagen, and unless selective estrogen receptor modulators such as Nolvadex or Clomid are taken in conjunction with the drug, there is a significant risk of the appearance of estrogenic effects such as gynaecomastia over time. Because of its 17α-alkylated structure, oxymetholone is highly hepatoxic. Long term use of the drug can cause a variety of serious ailments, including hepatitis, liver cancer, and cirrhosis. It is very dangerous to take Oxymetholone in high dosages for periods of time exceeding six weeks, and is commonly used by bodybuilders during the start of a steroid cycle to help gain mass and increase serum levels of androgens quickly.

Use with other steroids

To further increase its effectiveness as an anabolic agent, bodybuilders typically stack (see steroid stack) oxymetholone with other anabolic steroids. Since it is already a very potent androgen, many users will combine it with drugs such as nandrolone, Boldenone and Oxandrolone to further their gains.

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Fda Approves Androgel To Treat Male Testosterone Deficiency
From Worldwide Biotech, 4/1/00

Unimed Pharmaceuticals, Inc., Buffalo Grove, Ill., has announced that AndroGel(TM) 1% (testosterone gel) (C-III) has been approved by the U.S. Food and Drug Administration (FDA). The approval makes AndroGel(TM) the first-ever testosterone replacement gel to be approved by the FDA for replacement therapy in men for conditions associated with low testosterone. Low testosterone, also known as hypogonadism, affects approximately four to five million American men. The condition is linked with diminished interest in sex, impotence, reduced lean body mass, decreased bone density and lowered mood and energy levels. AndroGel(TM) will be available with a prescription in pharmacies throughout the United States by mid-summer. Unimed Pharmaceuticals, Inc. is a wholly owned subsidiary of Solvay Pharmaceuticals, Inc.

"We believe that doctors and men who are waiting for a more convenient testosterone treatment will regard AndroGel(TM) as a very attractive alternative to existing testosterone replacement therapy," said Robert E. Dudley, president and CEO, Unimed Pharmaceuticals, Inc. "AndroGel(TM) provides an easy, effective, invisible alternative to painful deep muscle injections and potentially irritating patches."

AndroGel(TM) is a unique, clear, colorless topical gel that men apply once daily to the shoulders, upper arms and/or abdomen. Upon application, AndroGel(TM) dries within a few minutes, during which time the skin absorbs the testosterone. The skin serves as a reservoir for the hormone, which slowly enters the bloodstream. Normal testosterone levels are restored soon after application. AndroGel(TM) is the only FDA approved testosterone replacement therapy available in gel form. AndroGel(TM) provides men with a safe, effective and easy-to-use treatment that can be applied at home.

Clinical data from a U.S. phase III study conducted in men with hypogonadism indicated that AndroGel(TM) quickly raised circulating testosterone to desirable levels, and maintained it within normal range. The study also found that AndroGel(TM) increased sex drive, bone mineral density, and lean body mass and improved mood and energy levels.

"Research supporting the use of AndroGel(TM) is extremely solid and the unique gel delivery method is very versatile," said Ronald S. Swerdloff, M.D., chief and professor of Medicine, Division of Endocrinology at Harbor-UCLA Medical Center. "Testosterone deficient men who use AndroGel(TM) can experience physical and psychological benefits with this convenient, well-tolerated gel."

Safety data from clinical studies of AndroGel(TM) demonstrate it to be well tolerated. Androgens are contraindicated in men with carcinoma of the breast, or known or suspected carcinoma of the prostate. Geriatric patients treated with androgens may be at an increased risk for the development of prostatic hyperplasia and prostatic carcinoma. AndroGel(TM) is not indicated for use in women and has not been evaluated in women. Pregnant women should avoid skin contact with AndroGel(TM) application sites in men. Testosterone may cause fetal harm.

Studies have shown that during vigorous skin to skin contact some of the testosterone in AndroGel(TM) can be transferred to the untreated individual. Residual testosterone on the skin can be removed with soap and water. Testosterone should not be used to improve athletic performance.

For full prescribing information, physicians and patients may visit www.Unimed.com or call 877-463-7645.

Unimed Pharmaceuticals, Inc., a wholly owned subsidiary of Solvay Pharmaceuticals, Inc., focuses on drugs with multiple indications in the therapeutic areas of hypertension, endocrinology, urology, HIV and other infectious diseases.

Unimed currently markets Teveten(R) (eprosartan mesylate) for the treatment of hypertension, Marinol (dronabinol) as an appetite stimulant for people living with HIV disease and as an antiemetic for people with cancer, Anadrol(R)-50 (oxymetholone) for the treatment of various anemias, and Maxaquin(R) (lomefloxacin HCl), a broad-spectrum quinolone antibiotic, for both complicated and uncomplicated urinary tract infections.

Solvay Pharmaceuticals, Inc. of Marietta, Georgia, is a research-based pharmaceuticals company, active in the therapeutic areas of cardiology, gastroenterology, mental health and women's health. It is a member of the worldwide Solvay Group of chemical and pharmaceutical companies, headquartered in Brussels, Belgium.

For more information, call 312-240-2841.

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