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Oxytetracycline

Oxytetracycline is known as a broad-spectrum antibiotic due to its activity against such a wide range of infections. It was the second of the Tetracyclines to be discovered. more...

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History

It was first found near Pfizer laboratories in a soil sample yielding the soil bacillus, Streptomyces rimosus. In 1953, a celebrated American biochemist, Robert B Woodward, son of a Scottish immigrant woman, worked out the chemical structure of Oxytetracycline, enabling Pfizer to mass produce the drug under the tradename, Terramycin. This discovery by Woodward was a major advancement in Tetracycline research and eventually lead to the synthesis of an Oxytetracycline derivative, Doxycycline, probably the most commonly used Tetracycline nowadays.

Indications

Oxytetracycline, like other Tetracyclines, is used to treat many infections common and rare (see Tetracycline antibiotics group). Its better absorption profile makes it preferable to tetracycline for moderately severe acne at a dosage of 250-500mg four times a day for usually 6-8 weeks at a time, but alternatives sould be sought if no improvement occurs by 3 months.

It is often used to treat Spirochaetal infection and Clostridium wound infection in patients sensitive to Penicillin.

The standard dose is 250-500mg six hourly by mouth. In particularly severe infections this dose may be increased accordingly. Occasionally, Oxytetracycline is given by intramuscular injection or topically in the form of cream or eyedrops.

Vetenary indications

Oxytetracycline is used to control the outbreak of American Foulbrood and European Foulbrood in honeybees.

Formulation

Tablets containing 250mg Tablets of Oxytetracycline as the dihydrate.

Read more at Wikipedia.org

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Protecting Against Blight
From Western Fruit Grower, 2/1/05

Cerexagri offers two new products that can help fruit growers control fire blight and bacterial spot.

FRUIT growers fighting diseases such as fire blight and bacterial spot will soon have a couple of new crop protection tools at their fingertips.

Cerexagri, which offers insect and disease control products for both preharvest and postharvest applications, has signed a supply agreement with AgroSource, Inc., a New Jersey crop protection company. The agreement covers two of AgroSource's products: PlameOut (oxytetracycline) and Firewall (streptomycin).

FlameOut controls fire blight on pears and bacterial blight on peaches and nectarines. The recommended concentration rate is 200 parts per million on pears, with repeat applications at four- to six-day intervals. The product should not be applied within 60 days of harvest. On peaches and nectarines, the recommended concentration rate is 150 parts per million. Application schedules are based on the shuck split stage of peaches, which varies by variety and region. FlameOut should not be applied within three weeks of harvest on peaches.

Wall Of Fire

Firewall controls fire blight on apples and pears and bacterial blight on vegetable crops such as potatoes, peppers, tomatoes, and celery. Application rates and use directions vary depending on the region. On apples, the recommended rate is 24 to 48 ounces per acre, applied at 20% to 30% bloom, every three to four days during blossom, and every 10 to 14 days after petal fall (on the West Coast, the recommended rate is 28.8 ounces per acre, applied at full bloom, at petal fall, and at late secondary bloom). Recommended rates and use directions are mostly the same on pears; however, on the West Coast, trees should be sprayed at 10% bloom and repeated at five-day intervals until late bloom is completed. Firewall should not be applied within 50 days of harvest on apples, and within 30 days of harvest on pears.

Both FlameOut and Firewall are compatible with most commonly used agricultural chemicals and can be used in resistance management programs. For more information on these products, contact Cerexagri at 800-438-6071, or go to the company's Web site at www.cerexagri.com.

E-mail questions or comments about this article to afg.edit@meistermedia.com.

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