Trenbolone

Trenbolone is an anabolic steroid used by veterinarians on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is not used in an unrefined form, but is rather administered as trenbolone acetate (Finaplix Gold from Valopharm USA, TREMBLONA QV75from Quality Vet, Mexico), or trenbolone cyclohexylmethylcarbonate (Parabolan from Laboratoires NEGMA until 1997). Trenbolone is then produced as a metabolite by the reaction of these compounds with the androgen receptor. more...

No trenbolone compounds have been approved by the FDA for human use, due to a lack of clinical applications and considerable negative side-effects. It is classified as a Schedule III drug under the Controlled Substances Act. However, bodybuilders have been known to use the drug illicitly in order to increase body mass more effectively than by weight training alone.

Trenbolone compounds have a binding affinity for the androgen receptor three times as high as that of testosterone. Once metabolised, the drugs have the effect of increasing nitrogen uptake by muscles, leading to an increase in the rate of protein synthesis. It also has the secondary effects of stimulating appetite, reducing the amount of fat being deposited in the body, and decreasing the rate of catabolism. Trenbolone has proven popular with anabolic steroid users as it is not metabolised by aromatase or 5α-reductase into estrogenic compounds such as estradiol, or into DHT. This means that it also does not cause any water retention normally associated with highly androgenic steroidal compounds like testosterone or methandrostenolone. It is also loved by many for the dramatic strength increases commonly experienced with it. Some short-term side effects include insomnia, high blood pressure and increased aggression and libido. However, since women will suffer virilization effects even at small doses, this drug should not be taken by a female. The use of the drug over extended periods of time can lead to kidney damage and sterility for both sexes. The kidney toxicity has not yet been proven.

A normal body-building dosage can range from 200mgs/week up to 500 plus mgs/week. Due to it's relatively short metabolic half-life, dosages should commonly be split into injections at least once every two days.

Trenbolone cyclohexymethylcarbonate has effects identical to those of trenbolone acetate as they produce the same active metabolite, but has a significantly longer elimination half-life: up to a week rather than one or two days.

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