Verapamil chemical structure
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Verapamil

Verapamil (brand names: Isoptin®, Verelan®, Calan®) is a medical drug that acts as an L-type calcium channel blocker. It is used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. more...

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Verapamil is generally effective for migraine but it takes about 2 weeks to work. Verapamil is effective in migraine variants such as hemiplegic migraine (Yu and Horowitz, 2003). It also may be helpful in Menieres disease, although this has not yet been documented by a controlled study. Nimodipine has been reported to be helpful for Meniere's disease.

Verapamil is a class IV antiarrhythmic agent, and decreases conduction through the AV node.

Some possible side effects of the drug are headaches, facial flushing, dizziness, swelling, and constipation.

Verapamil is also used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein. This is useful as many tumor cell lines overexpress drug efflux pumps, limiting the effectiveness of cytotoxic drugs or fluorescent tags. Its also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorochromes such as Hoechst 33342.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Source

  • Annu Rev Pharmacol Toxicol. 1996;36:161-8. P-glycoproteins and multidrug resistance. Bellamy WT.


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Differential diagnosis is crucial in handling cluster headache: exclude secondary headache.(Clinical Rounds) : An article from: Family Practice News $5.95 Quinidine/Verapamil Excel in Recurrent Atrial Fib. (Better Than Sotalol After Cardioversion).(fibrillat ion ) : An article from: Internal Medicine News $5.95
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Verapamil - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References $48.95 Calcium Channel Antagonists in Cardiovascular Disease: Focus on Verapamil $8.14
Verapamil does not inhibit (99m)TcN-NOET uptake in situ in normal or ischemic canine myocardium : An article from: The Journal of Nuclear Medicine $20.00 Cardiovascular effects of verapamil (The Landmark series of medical & scientific articles) $18.00

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