Vinorelbine chemical structure
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Vinorelbine

Vinorelbine (Navelbine®) is a chemotherapy drug that is given as a treatment for some types of cancer, including breast cancer and non-small-cell lung cancer. more...

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Pharmacolgy

Vinorelbine is a vinca alkaloid. It is obtained by semi-synthesis from alkaloids extracted from the rosy periwinkle, Catharanthus roseus.

History

Vinorelbine was invented in the 1980s by scientists at the pharmaceutical arm of the Pierre Fabre Group. The drug was approved in France in 1989 under the brand name Navelbine for the treatment of bronchial cancer. It gained approval to treat non-small cell lung cancer in 1991 and this cancer is what the drug is now primarily used to treat. Vinorelbine received FDA approval in December 1994 sponsored by GlaxoSmithKline. The drug went generic in the US in February 2003.

Side-effects

Vinorelbine has a number of side-effects that can limit its use:

Lowered resistance to infection, bruising or bleeding, anaemia, constipation, diarrhoea, nausea, numbness or tingling in hands or feet (peripheral neuropathy), tiredness and a general feeling of weakness (asthenia), inflammation of the injected vein (phlebitis).

Less common effects are hair loss, allergic reaction.


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Gale Encyclopedia of Cancer : Vinorelbine $2.30

Phase II study of neoadjuvant chemotherapy with gemcitabine and vinorelbine in resectable non-small cell lung cancer
Objective: We assessed the efficacy of a non-platinum-containing doublet chemotherapy of gemcitabine and vinorelbine as induction therapy prior to surgical ...
Vinorelbine induced interstitial pneumonitis: a case report
INTRODUCTION: Vinorelbine (Navalbine), a newer Vinca alkaloid has been increasingly used in the chemotherapy of non-small-cell Bronchogenic carcinoma ...
A Multicenter Phase II Trial of Vinorelbine Plus Gemcitabine in Previously Untreated Inoperable Non-small Cell Lung Cancer - Stage IIIB/IV - )
Study objective: Vinorelbine and gemcitabine are two active single agents used in the treatment of non-small cell lung cancer (NSCLC). A clinical trial ...
Fatal Pulmonary Toxicity Resulting From Treatment With Gemcitabine And Vinorelbine Association
Purpose: Case 1: A 69 years old man had an extensive NSCLC. Gemcitabine (800 mg/m2) and vinorelbine (25 mg/m2) were given weekly. 7 days after the ninth ...
Vinorelbine
Definition Vinorelbine is a drug used to treat certain types of cancer. Vinorelbine is available under the trade name Navelbine. The drug may also ...
Adjuvant chemotherapy for early-stage non-small cell lung cancer
Lung cancer is the leading cause of cancer-related mortality in the developed world. Non-small cell lung cancer (NSCLC) represents 85% of cases of lung ...
Respiratory failure following vinorelbine tartrate infusion in a patient with non-small cell lung cancer
Vinorelbine tartrate (Navelbine [Burroughs Wellcome Research Triangle Park, NC; Pierre Fabre Medicament; Paris, France]) is used in the treatment of ...
Chemotherapy for elderly patients with non-small cell lung cancer : a review of the evidence
Chemotherapy for elderly patients with non-small cell lung cancer (NSCLC) has been questioned due to the perceived potential for higher toxicity in this population, possibly attributable to progres

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