Drugs for Non-HIV viral infections. The Medical Letter 2002;44(1123):9-16
This issue updates recommendations regarding drugs for nonhuman immunodeficiency viral infections, including a table that outlines drugs of choice, dosages, and costs. Oral acyclovir or famciclovir decrease the symptomatic frequency of genital herpes and reduce asymptomatic herpes simplex virus shedding. If begun within 24 hours after rash onset, acyclovir decreases varicella severity. You can use both drugs to treat localized or disseminated zoster.
For the treatment of chronic hepatitis C virus, researchers state that treatment with parenteral interferon alfa and oral ribavirin (Rebetol, Virazole) has higher response rates than therapy with either drug alone. Newer pegylated interferons (alfa-2a or alfa2b) have a longer half-life, require fewer doses, and are more effective than standard alfa interferon. In one study, interferon alfa-2b treatment prevented most chronic infections in patients with acute hepatitis C virus. The authors also review amantadine, cidofovir, fomivirsen, foscarnet, ganciclovir, lamivudine, oseltamivir, penciclovir, valacyclovir, trifluridine, valganciclovir, and zanamivir.
Nancy Risser, MN, RN,C, ANP
Mary Murphy, CPNP, PhD
Literature Review Editors
Literature Review offers succinct summaries of articles published in recent clinical journals.
The journals reviewed include: American Family Physician - American Journal of Medicine - American Journal of Psychiatry - American Journal of Respiratory and Critical Care Medicine - Annals of Internal Medicine - Archives of Pediatric and Adolescent Medicine - CA: A Cancer Journal for Clinicians - Cancer - Clinical Pediatrics - Journal of Emergency Medicine - Journal of the American Geriatrics Society - Journal of the American Medical Association - Journal of Pediatric Health Care - Obstetrics and Gynecology - Lancet - Mayo Clinic Proceedings - MCN: The American Journal of Maternal/Child Nursing - The Medical Letter Morbidity and Mortality Weekly Report - Now England Journal of Medicine - Pediatric Annals Pediatric Nursing - Pediatrics - Pediatrics in Review
Copyright Springhouse Corporation Aug 2002
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