GlaxoSmithKline is changing the label of Valtrex (valacyclovir) caplets to reflect new data on nursing mothers. After oral administration of 500 mg of the drug, five nursing mothers had peak acyclovir concentrations in breast milk ranging from 0.5 to 2.3 times the corresponding maternal acyclovir serum concentrations. A 500-mg dosage of Valtrex twice daily would provide a nursing infant with an oral acyclovir dosage of approximately 0.6 mg/kg per day--less than 2% of the exposure obtained after administration of a standard neonatal dosage of 30 mg/kg per day of intravenous acyclovir. For more information, contact GlaxoSmithKline by calling 888-825-5249.
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