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Brucellosis

Brucellosis (Undulant fever or Malta fever) is an infectious disease caused by the Brucella bacteria, which induces inconstant fevers, sweating, weakness, anorexia, headaches, depression and muscular and bodily pain. The popular name of the condition is originated due to the inconstance (or undulance) of the fever, which raises and falls constantly. Brucellosis is named after its researcher David Bruce. more...

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The disease is transmitted either through contaminated or untreated milk (and its derivates) or through direct contact with infected animals, which may include sheep, pigs, goats, cattle, camels, bison, and other ruminants. This also includes contact with their carcasses.

In animals this disease is also known as contagious abortion and infectious abortion. In 1897 Danish veterinarian Bernhard Bang isolated Brucella abortus as the agent and the additional name Bang's disease was assigned. In modern usage "Bang's disease" is often corrupted to just "bangs" when ranchers discuss the disease or vaccine.

The incubation period of brucellosis is, usually, of one to three weeks, but some rare instances may take several months to surface. The symptoms are like those associated with many other febrile diseases, but with emphasis on muscular pain and sweating. The duration of the disease can vary from a few weeks to many months.

The disease's sequelae are highly variable and may include granulomatous hepatitis, arthritis, spondylitis, anemia, leukopenia, thrombocytopenia, meningitis, uveitis, optic neuritis and endocarditis.

Antibiotics like tetracyclins, chloramphenicol, rifampin and the aminoglycosides streptomycin and gentamicin are effective against Brucella bacteria. However, the use of more than one antibiotic is needed for several weeks, due to the fact that the bacteria incubates within cells.

The main way of preventing Brucellosis is the proper pasteurization of all milk that is to be ingested by human beings, either in its pure form or as a derivate, such as cheese.

Read more at Wikipedia.org


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Good guys and bad guys share tactics - genetic research on brucellosis pathogen and Rhizobium meliloti - Brief Article
From Science News, 4/8/00 by

Both members of a microbial odd couple--the brucellosis pathogen and a symbiotic bacteriumin plants--depend on the same gene to settle into their hosts.

The discovery raises hopes for a vaccine to protect people from brucellosis, say Kristin LeVier of the Massachusetts Institute of Technology and her colleagues in the March 31 SCIENCE.

The hard-to-treat disease wracks people with fever and causes abortion in livestock. Vigilance has nearly stamped out U.S. cases, except among Yellowstone bison and elk. However, brucellosis still troubles other countries.

At the other end of the usefulness spectrum, Rhizobium meliloti settles into nodules on legume roots and converts atmospheric nitrogen into the form that plants need.

Earlier work showed that R. meliloti invades cells but can't establish itself without the bacA gene. LeVier and her colleagues found that Brucella abortus with defective bacA enters mouse cells but can't create a chronic infection.

COPYRIGHT 2000 Science Service, Inc.
COPYRIGHT 2000 Gale Group

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