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Ectodermal Dysplasia

ED is not a single disorder, but a group of closely related conditions. More than 150 different syndromes have been identified.

Ectodermal Dysplasias are described as "heritable conditions in which there are abnormalities of two or more ectodermal structures such as the hair, teeth, nails, sweat glands, cranial-facial structure, digits and other parts of the body."

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Stem cells can help new teeth grow
From Chicago Sun-Times, 2/20/05

BETHESDA, Md. -- When he was a child, biochemist Jonathan Schuermann loved to ride roller coasters. But before every ride, he had to give his dentures to his father, who feared they would fall out when Schuermann screamed.

Afflicted with a rare genetic disorder, ectodermal dysplasia, Schuermann, 27, of San Antonio had only four pointed teeth at age 3, when he got his first set of dentures. Although he got dental implants at 12, he is excited about a discovery announced last week - - that adult stem cells harvested from baby or wisdom teeth may allow him and others to grow new teeth naturally.

Pamela Gehron Robey of the National Institute of Dental and Craniofacial Research said stem cells from baby teeth can develop into tooth-generating cells. Scientists transplanted the cells into mice and found that it induced the formation of bone and dentin, the hard substance under tooth enamel.

The discovery also holds great promise for restoring tissues destroyed by gum diseases such as gingivitis and periodontitis, Robey said.

Scripps Howard News Service

Copyright The Chicago Sun-Times, Inc.
Provided by ProQuest Information and Learning Company. All rights Reserved.

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