SAN DIEGO -- Transdermal ketoprofen, an investigational topical agent, appears to be effective in reducing self-reported delayed-onset muscle soreness after repetitive musde contraction, especially after 48 hours, Christopher Cannavino reported at the annual meeting of the American Medical Society for Sports Medicine.
Last year, Mr. Cannavino and his associates in the division of sports medicine at the University of California, San Diego, enrolled 32 men aged 18-35 in a doubleblind, placebo-controlled clinical trial.
At baseline and 24 hours, the men carried out knee extension and flexion exercise loads on each isolated quadriceps muscle. They performed maximal-effort isometric contractions at multiple joint angles, then completed as many dynamic variable resistance repetitions as possible at 40% of the peak torque generated during the isometric test. Subjects carried out this procedure twice on each leg per exercise session, said Mr. Cannavino, a 2ndyear medical student at UCSD.
Immediately following the exercise and every 8 hours thereafter, the subjects applied an intervention cream (10% ketoprofen in a Pluronic lecithin organogel) or a placebo cream (Pluronic lecithin organogel) to their quadriceps muscles. The subjects were randomized into four groups that applied different combinations of intervention and placebo to their right and left quadriceps.
The investigators evaluated muscle soreness at baseline, 24 hours, and 48 hours using a subjective soreness scale, with 0 representing "no soreness" and 10 representing "worst soreness." They also measured systemic absorption of ketoprofen at 24 and 48 hours through analysis of serum samples.
Subjects in the groups that administered transdermal ketoprofen to one leg and placebo cream to the other leg reported significantly less soreness in the leg treated with ketoprofen, compared with the leg treated with placebo.
Subjects in the group that applied ketoprofen to both legs reported significantly less soreness at 48 hours, compared with subjects in the group that received placebo cream on both legs.
Systemic absorption of transdermal ketoprofen was low, with a trend toward higher serum ketoprofen in subjects who received ketoprofen on both legs.
Mr. Cannavino and his associates observed no differences in postexercise function scores of men whose legs received ketoprofen, compared with those who received placebo cream.
There were no reports of adverse reactions to the creams.
COPYRIGHT 2000 International Medical News Group
COPYRIGHT 2001 Gale Group
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