Wymox

Infections of the urinary tract are common--only respiratory infections occur more often. Each year, urinary tract infections (UTI's) account for about 8 million doctor visits. Women are especially prone to UTI's for reasons that are poorly understood. One woman in five develops a UTI during her lifetime.

The urinary system consists of the kidneys, ureters, bladder, and urethra. The key players in the system are the kidneys, a pair of purplish-brown organs located below the ribs toward the middle of the back. The kidneys remove liquid waste from the blood in the form of urine, keep a stable balance of salts and other substances in the blood, and produce a hormone that aids the formation of red blood cells. Narrow tubes called ureters carry urine from the kidneys to the bladder, a triangle-shaped chamber in the lower abdomen. Urine is stored in the bladder and emptied through the urethra.

The average adult passes about a quart and a half of urine each day. The amount of urine varies, depending on the fluids and foods a person consumes. The volume formed at night is about half that formed in the daytime.

Causes

Normal urine is sterile. It contains fluids, salts, and waste products, but it is free of bacteria, viruses, and fungi. An infection occurs when microorganisms, usually bacteria from the digestive tract, cling to the opening of the urethra and begin to multiply. Most infections arise from one type of bacteria, Escherichia coli (E. coli), which normally live in the colon.

In most cases, bacteria first begin growing in the urethra. An infection limited to the urethra is called urethritis. From there bacteria often move on to the bladder, causing a bladder infection (cystitis). If the infection is not treated promptly, bacteria may then go up the ureters to infect the kidneys (pyelonephritis).

Microorganisms called Chlamydia and Mycoplasma may also cause UTI's in both men and women, but these infections tend to remain limited to the urethra and reproductive system. Unlike E. coli, Chlamydia and Mycoplasma may be sexually transmitted, and infections require treatment of both partners.

The urinary system is structured in a way that helps ward off infection. The ureters and bladder normally prevent urine from backing up toward the kidneys, and the flow of urine from the bladder helps wash bacteria out of the body. In men, the prostate gland produces secretions that slow bacterial growth. In both sexes, immune defenses also prevent infection. Despite these safeguards, though, infections still occur.

Who is at Risk

Some people are more prone to getting a UTI than others. Any abnormality of the urinary tract that obstructs the flow of urine (a kidney stone, for example) sets the stage for an infection. An enlarged prostate gland also can slow the flow of urine, thus raising the risk of infection.

A common source of infection is catheters, or tubes, placed in the bladder. A person who cannot void, is unconscious or critically ill, often needs a catheter that stays in place for a long time. Some people, especially the elderly or those with nervous system disorders who lose bladder control, may need a catheter for life. Bacteria on the catheter can infect the bladder, so hospital staff take special care to keep the catheter sterile and remove it as soon as possible.

People with diabetes have a higher risk of a UTI because of changes of the immune system. Any disorder that suppresses the immune system raises the risk of a urinary infection.

UTI's may occur in infants who are born with abnormalities of the urinary tract, which sometimes need to be corrected with surgery. UTI's are rarely seen in boys and young men. In women, though, the rate of UTI's gradually increases with age. Scientists are not sure why women have more urinary infections than men. One factor may be that a woman's urethra is short, allowing bacteria quick access to the bladder. Also, a woman's urethral opening is near sources of bacteria from the anus and vagina. For many women, sexual intercourse seems to trigger an infection, although the reasons for this linkage are unclear.

According to several studies, women who use a diaphragm are more likely to develop a UTI than women who use other forms of birth control. Recently, researchers found that women whose partners use a condom with spermicidal foam also tend to have growth of E. coli bacteria in the vagina.

Recurrent Infections

Many women suffer from frequent UTI's. Nearly 20 percent of women who have a UTI will have another, and 30 percent of those will have yet another. Of the last group, 80 percent will have recurrences.

Usually, the latest infection stems from a strain or type of bacteria that is different from the infection before it, indicating a separate infection. (Even when several UTI's in a row are due to E. coli, slight differences in the bacteria indicate distinct infections.)

Research funded by the National Institutes of Health (NIH) suggests that one factor behind recurrent UTI's may be the ability of bacteria to attach to cells lining the urinary tract. A recent NIH-funded study has also shown that women with recurrent UTI's tend to have certain blood types. Some scientists speculate that women with these blood types are more prone to UTI's because the cells lining the vagina and urethra may allow bacteria to attach more easily. Further research will show whether this association is sound and proves useful in identifying women at high risk for UTI's.

Infections in Pregnancy

Pregnant women seem no more prone to UTI's than other women. However, when a UTI does occur, it is more likely to travel to the kidneys. According to some reports, about 2 to 4 percent of pregnant women develop a urinary infection. Scientists think that hormonal changes and shifts in the position of the urinary tract during pregnancy make it easier for bacteria to travel up the ureters to the kidneys. For this reason, many doctors recommend periodic testing of urine.

Symptoms

Not everyone with a UTI has symptoms, but most people get at least some. These may include a frequent urge to urinate and a painful, burning feeling in the area of the bladder or urethra during urination. It is not unusual to feel bad all over--tired, shaky, washed out--and to feel pain even when not urinating. Often, women feel an uncomfortable pressure above the pubic bone, and some men experience a fullness in the rectum. It is common for a person with a urinary infection to complain that, despite the urge to urinate, only a small amount of urine is passed. The urine itself may look milky or cloudy, even reddish if blood is present. A fever may mean that the infection has reached the kidneys. Other symptoms of a kidney infection include pain in the back or side below the ribs, nausea, or vomiting.

In children, symptoms of a urinary infection may be overlooked or attributed to another disorder. A UTI should be considered when a child or infant seems irritable, is not eating normally, has an unexplained fever that does not go away, has incontinence or loose bowels, or is not thriving. The child should be seen by a doctor if there are any questions about these symptoms, especially if there is a change in the child's urinary pattern.

Diagnosis

To find out whether you have a UTI, your doctor will test a sample of urine for pus and bacteria. You will be asked to give a "clean catch" urine sample by washing the genital area and collecting a "midstream" sample of urine in a sterile container. (This method of collecting urine helps prevent bacteria around the genital area from getting into the sample and confusing the test results.) Usually, the sample is sent to a laboratory, although some doctors' offices are equipped to do the testing.

In the urinalysis test, the urine is examined for white and red blood cells and bacteria. Then the bacteria are grown in a culture and tested against different antibiotics to see which drug best destroys the bacteria. This last step is called a sensitivity test.

Some microbes, like Chlamydia and Mycoplasma, can only be detected with special bacterial cultures. A doctor suspects one of these infections when a person has symptoms of a UTI and pus in the urine, but a standard culture fails to grow any bacteria.

When an infection does not clear up with treatment and is traced to the same strain of bacteria, the doctor will order a test that makes images of the urinary tract. One of these tests is an intravenous pyelogram (IVP), which gives x-ray images of the bladder, kidneys, and ureters. An opaque dye visible on x-ray film is injected into a vein, and a series of x-rays are taken. The film shows an outline of the urinary tract, revealing even small changes in the structure of the tract.

If you have recurrent infections, your doctor also may recommend an ultrasound exam, which gives pictures from the echo patterns of soundwaves bounced back from internal organs. Another useful test is cystoscopy. A cystoscope is an instrument made of a hollow tube with several lenses and a light source, which allows the doctor to see inside the bladder from the urethra.

Treatment

UTI's are treated with antibacterial drugs. The choice of drug and length of treatment depends on the patient's history and the urine tests that identify the offending bacteria. The sensitivity test is especially useful in helping the doctor select the most effective drug. The drugs most often used to treat routine, uncomplicated UTI's are trimethoprim (Trimpex), trimethoprim/sufamethoxazole (Bactrim, Septra, Cotrim), amoxicillin (Amoxil, Trimox, Wymox), nitrofurantoin (Macrodantin, Furadantin), and ampicillin.

Often, a UTI can be cured with 1 or 2 days of treatment if the infection is not complicated by an obstruction or nervous system disorder. Still, many doctors ask their patients to take antibiotics for a week or two to assure that the infection has been cured. Single-dose treatment is not recommended for some groups of patients, for example, those who have delayed treatment or have signs of a kidney infection, patients with diabetes or structural abnormalities, or men who have prostate infections. Longer treatment is also needed by patients with infections caused by Mycoplasma or Chlamydia, which are usually treated with tetracycline, trimethoprim/sulfamethoxazole (TMP/SMZ), or doxycycline. A followup urinalysis helps to confirm that the urinary tract is infection-free. It is important to take the full course of treatment because symptoms may disappear before the infection is fully cleared.

Severely ill patients with kidney infections may be hospitalized until they can take fluids and needed drugs on their own. Kidney infections generally require several weeks of antibiotic treatment. Researchers at the University of Washington found that 2-week therapy with TMP/SMZ was as effective as 6 weeks of treatment with the same drug in women with kidney infections that did not involve an obstruction or nervous system disorder. In such cases, kidney infections rarely lead to kidney damage or kidney failure unless they go untreated.

Various drugs are available to relieve the pain of a UTI. A heating pad or a warm bath may also help. Most doctors suggest that drinking plenty of water helps cleanse the urinary tract of bacteria. For the time being, it is best to avoid coffee, alcohol, and spicy foods. (And one of the best things a smoker can do for his or her bladder is to quit smoking. Smoking is the major known cause of bladder cancer.)

Recurrent Infections in Women

About 4 out of 5 women who have a UTI get another in 18 months. Many women have them even more often. A woman who has frequent recurrences (three or more a year) should ask her doctor about one of the following treatment options:

* Take low doses of an antibiotic such as TMP/SMZ or nitrofurantoin daily for 6 months or longer. (If taken at bedtime, the drug remains in the bladder longer and may be more effective.) NIH-supported research at the University of Washington has shown this therapy to be effective without causing serious side effects.

* Take a single dose of an antibiotic after sexual intercourse.

* Take a short course (1 or 2 days) of antibiotics when symptoms appear.

Dipsticks that change color when an infection is present are now available without prescription. The strips detect nitrite, which is formed when bacteria change nitrate in the urine to nitrite. The test can detect about 90 percent of UTI's and may be useful for women who have recurrent infections.

Doctors suggest some additional steps that a woman can take on her own to avoid an infection:

* Drink plenty of water every day. Some doctors suggest drinking cranberry juice, which in large amounts inhibits the growth of some bacteria by acidifying the urine. Vitamin C (Ascorbic Acid) supplements have the same effect.

* Urinate when you feel the need; don't resist the urge to urinate;

* Wipe from front to back to prevent bacteria around the anus from entering the vagina or urethra;

* Take showers instead of tub baths;

* Cleanse the genital area before sexual intercourse;

* Empty the bladder shortly before and after sexual intercourse; and

* Avoid using feminine hygiene sprays and scented douches, which may irritate the urethra.

Infections in Pregnancy

A pregnant woman who develops a UTI should be treated promptly to avoid premature delivery of her baby and other risks such as high blood pressure. Some antibiotics are not safe to take during pregnancy. In selecting the best treatment, doctors consider various factors such as the drug's effectiveness, the stage of pregnancy, the mother's health, and potential effects on the fetus.

Complicated Infections

Curing infections that stem from a urinary obstruction or nervous system disorder depends on finding and correcting the underlying problem, sometimes with surgery. If the root cause goes untreated, this group of patients is at risk of kidney damage. Also, such infections tend to arise from a wider range of bacteria, and sometimes from more than one type of bacteria at a time.

UTI's are unusual in men. They usually stem from an obstruction--for example, a urinary stone or enlarged prostate--or a medical procedure involving a catheter. The first step is to identify the infecting organism and the drugs to which it is sensitive. Usually, doctors recommend lengthier therapy in men than in women, in part to prevent infection of the prostate gland. Prostate infections (prostatitis) are harder to cure because antibiotics are unable to penetrate infected prostate tissue effectively. For this reason, men with prostatitis often need long-term treatment with a carefully selected antibiotic.

Research in Urinary System Disorders

The NIH conducts and supports a variety of research in diseases of the kidney and urinary tract. The knowledge gained from these studies is advancing scientific understanding of why UTI's develop and is leading to improved methods of diagnosing, treating, and preventing infections.

The National Institute of Diabetes and Digestive and Kidney Diseases, part of the NIH, has established six research centers around the country with the goal of reducing the major causes of kidney and urinary tract diseases through innovative research. The lead researchers, their institutions, and research focus are listed on the following pages.

GEORGE M. O'BRIEN KIDNEY AND UROLOGICAL RESEARCH CENTERS

Barry M. Brenner, M.D.

Division of Nephrology

Brigham and Women's Hospital

75 Francis Street

Boston, Massachusetts 02115

(617) 732-5850

Kidney Disease of Diabetes Mellitus

Kidney Transplant Rejection

Roger C. Wiggins, M.D.

Division of Nephrology

University of Michigan

3914 Taubman Center

1500 East Medical Center Drive

Ann Arbor, Michigan 48109-0364

(313) 936-5645

Glomerulonephritis

Harry R. Jacobson, M.D.

Vanderbilt University

School of Medicine

53223 Medical Center North

21st Avenue, South

Nashville, Tennessee 37232-2732

(615) 322-4794

Progressive Glomerular Sclerosis

Kidney Transplant Rejection

David G. Warnock, M.D.

Division of Nephrology

University of Alabama at Birmingham

Room 647 THT, UAB Station

Birmingham, Alabama 35294

(205) 934-3585

Effects of High Blood Pressure on the Kidney

Glomerulonephritis, Interstitial Nephritis

Ahmad Elbadawi, M.D.

SUNY Upstate Center

750 East Adams Street

Syracuse, New York 13210

(315) 464-5737

Urinary Tract Obstruction

John T. Grayhack, M.D.

Department of Urology

Northwestern University

Medical School

303 East Chicago Avenue

Chicago, Illinois 60611

(312) 908-8145

Prostate Enlargement

Suggestions for Additional Reading

The following materials can be found in medical libraries, many college and university libraries, and through interlibrary loan in most public libraries.

Corriere, Joseph N. Jr. et al., "Cystitis: Evolving Standard of Care." Patient Care, Feb. 29, 1988, pp. 33-47.

Fowler, Jackson E. Jr., "Urinary Tract Infections in Women." Urologic Clinics of North America, Nov. 1986, pp. 673-683.

Gillenwater, Jay Y. et al., eds. Adult and Pediatric Urology, vol. 1. Chicago: Yearbook Medical Publishers, 1987.

Goldman, Peggy L. et al., "Evaluating Dysuria in the Era of STDs"' Patient Care, January 15, 1991, pp. 51-69.

Hooton, Thomas M. et al., "Escherichia coli Bacteriuria and Contraceptive Method," Journal of the American Medical Association, January 2, 1991,'pp. 64-69.

Krieger, John N., "Complications and Treatment of Urinary Tract Infections During Pregnancy," Urologic Clinics of North America, Nov. 1986, pp. 685-693.

Kunin, Calvin M. Detection; Prevention and Management of Urinary Tract Infections, 4th edition. Philadelphia: Lea and Febiger, 1987.

Prostate Enlargement: Benign Prostatic Hyperplasia. A patient education booklet prepared by the National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 1991.

Sheinfeld, Joel et al., "Association of the Lewis Blood-Group Phenotype with Recurrent Urinary Tract Infections in Women'" New England Journal of Medicine, March 23, 1989, pp 773-776.

Spencer, Julia R., and Schaeffer, Anthony J., "Pediatric Urinary Tract Infections," Urologic Clinics of North America, Nov. 1986, pp. 661-672.

Stamm, Walter E. et al., "Acute Renal Infection in Women: Treatment with Trimethoprim-Sulfamethoxazole or Ampicillin for Two or Six Weeks: A Randomized Trial" Annals of Internal Medicine, March 1987, pp. 341-345.

Stapleton, Ann et al., "Postcoital Antimicrobial Prophylaxis for Recurrent Urinary Tract Infection: a randomized, double-blind, placebo-controlled trial," Journal of the American Medical Association, August 8, 1990, pp. 703-706.

Walsh, Patrick C. et al., eds. Campbell's Urology, vol 1. 5th edition. Philadelphia: W.B. Saunders, 1986.

Additional Information

The NIDDK sponsors the National Kidney and Urologic Diseases Information Clearinghouse, which collects and produces information about kidney and urinary tract disorders for health professionals and the public. For information about kidney and urinary tract disorders, contact the National Kidney and Urologic Diseases Information Clearinghouse, Box NKUDIC, 9000 Rockville Pike, Bethesda, MD 20892, telephone (301) 468-6345.

COPYRIGHT 1991 U.S. Department of Health and Human Services
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