Fludarabine is a chemotherapy drug used in the firstline treatment of chronic lymphocytic leukemia. Because of its immunosuppression, fludarabine is also used in some conditioning regimens of non myeloablative allogeneic transplant. more...
It is a purine analog, and is given intravenously. Fludarabine inhibits DNA synthesis by interering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells.
Fludarabine is associated with profound lymphocytopenia, and as a consequence, increases the risk of opportunistic infections significantly.
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