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Fludarabine

Fludarabine is a chemotherapy drug used in the firstline treatment of chronic lymphocytic leukemia. Because of its immunosuppression, fludarabine is also used in some conditioning regimens of non myeloablative allogeneic transplant. more...

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It is a purine analog, and is given intravenously. Fludarabine inhibits DNA synthesis by interering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells.

Fludarabine is associated with profound lymphocytopenia, and as a consequence, increases the risk of opportunistic infections significantly.

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Distinguish Fludarabine-Induced Lung Toxicity From Infection.(Brief Article) : An article from: Family Practice News $5.95 Gale Encyclopedia of Cancer : Fludarabine $3.10

Fludarabine-related pulmonary toxicity : a distinct clinical entity in chronic lymphoproliferative syndromes - clinical investigations
Background: Little is known about lung injury caused by fludarabine therapy. Objectives: To establish a case definition, to describe management, and ...
Distinguish Fludarabine-Induced Lung Toxicity From Infection - Brief Article
BETHESDA, MD. -- The chemotherapy agent fludarabine can induce pulmonary toxicity that resembles the symptoms of pulmonary infection, Dr. Donald L. Helman reported at the annual meeting of the Wash
Leukemia drug approved - fludarabine approved for treatment of chronic lymphocytic leukemia
FDA has approved fludarabine, an "orphan" drug that offers people with the most common form of adult leukemia--chronic lymphocytic leukemia, or CLL-an ...
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Definition Fludarabine is a chemotherapy medicine used to treat certain types of cancer by destroying cancerous cells. It is known as the ...
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We present a case of a 49-year-old man previously diagnosed with chronic myelogenous leukemia. His bone marrow biopsy showed a complex triple translocation ...
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Hairy cell leukemia variant (HCL-V) is a rare lymphoproliferative disorder. We report a case of HCL-V with an intrasinusoidal pattern of bone marrow involvement ...
Pilot Clinical Study of Genasense® Plus Rituxan® and Fludarabine Shows Activity in Chronic Lymphocytic Leukemia
Study Supports Safety and Potential Activity for the Regimen ATLANTA, Ga., Dec. 12 /PRNewswire-FirstCall/ -- Genta Incorporated announced the presentation ...
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