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Imipenem

Imipenem is an intravenous beta-lactam antibiotic developed in 1985. Imipenem belongs to the subgroup of carbapenems. It is derived from a compound called thienamycin, which is produced by the bacteria Streptomyces cattley. Imipenem has a broad spectrum of activity against aerobic and anaerobic Gram positive as well as Gram negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species. It is not active against methicillin-resistant Staphylococcus aureus, however. more...

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Imipenem is unique in that it is degraded by the kidney before working when given alone. Therefore, it is used in combination with cilastatin. Cilastatin stops the kidney from degrading imipenem and itself has no intrinsic antibacterial activity. An example of an Imipenem / Cilastatin combination therapy is the Merck drug Primaxin (also marketed internationally as Tienam).

Common side effects are nausea and vomiting. People who are allergic to penicillin and other beta-lactam antibiotics should not take imipenem. Imipenem can also cause seizures.

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Carbapenems and monobactams: Imipenem, meropenem, and aztreonam : An article from: Mayo Clinic Proceedings $20.00 Imipenem resistance in nonfermenters causing nosocomial urinary tract infections. : An article from: Indian Journal of Medical Sciences $5.95
Imipenem/Cilastatin: Experience With a Long Acting Intramuscular Formulation (Chemotherapy, Vol 37, Suppl 2, 1991) $18.50

Effects of manipulation of N-methyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats
Background & objectives: Epileptic seizures have been reported in patients on imipenem/cilastatin (Imi/Cil) therapy. To investigate contribution of N-methyl-D-aspartate ...
Use of imipenem in the treatment of pulmonary nocardiosis
A case of pulmonary nocardiosis with empyema in a 55-year-old man with macroglobulinemic lymphoma is presented. Treatment with imipenem followed by oral trimethoprim-sulfamethoxazole (TMP-SMX) reso
Imipenem for empiric therapy in febrile neutropenic patients - Tips from Other Journals
A major cause of morbidity and mortality in neutropenic patients is serious infection. As the neutrophil count decreases below [10.sup.6] per L, the ...
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Impact of clinical guidelines in the management of severe hospital-acquired pneumonia
Study objectives: To asses the impact of locally developed antimicrobial treatment guidelines in the initial empiric treatment of ICU patients with severe hospital-acquired pneumonia (HAP). Desig
Atypical infections in tsunami survivors
After a tsunami hit Asia in December 2004, 2 survivors had severe infections due to multidrug-resistant and atypical bacteria and rare fungi weeks afterwards.

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