A rhabdomyosarcoma is a type of cancer, specifically a sarcoma (cancer of connective tissues), in which the cancer cells arise from skeletal muscle. It can also be found attached to muscle tissue, wrapped around intestines, or anywhere, to include the neck area. more...
It is most common in children ages one to five, and teens aged 15 to 19, although quite rare in the latter.
It can be a cardiac manifestation of tuberous sclerosis.
When rhabdomyosarcoma is suspected, tests will be run for blood, muscle, and marrow.
Diagnosis of rhabdomyosarcoma depends on recognition of differentiation toward skeletal muscle cells. The protein myo D1 is a protein normally found in developing skeletal muscle cells which disappears after the muscle matures and becomes innervated by a nerve. Thus, myo D1 is not found in normal skeletal muscle and serves as a useful histochemical marker of rhabdomyosarcoma.
Treatment for rhabdomyosarcoma consists of chemotherapy and radiation therapy. The prognosis is good for any patients being as the cancer generally responds very well to chemotherapy. Some cases show a 75 percent reduction after the first and second rounds of chemotherapy. Some patients have shown a 90% decrease in the size of their tumors within a few months after chemotherapy. Usually surgery is required after chemotherapy to remove existing cancer, although some cases have shown the disease to be so reduced that no surgery is necessary following chemotherapy.
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