Linezolid chemical structure
Find information on thousands of medical conditions and prescription drugs.

Zyvox

Linezolid is a synthetic systemic antibiotic drug. more...

Home
Diseases
Medicines
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Zafirlukast
Zagam
Zalcitabine
Zaleplon
Zanaflex
Zanamivir
Zantac
Zarontin
Zelnorm
Zerit
Zestoretic
Zestril
Zetia
Zevalin
Ziagen
Zidovudine
Zileuton
Ziprasidone
Zithromax
Zocor
Zofran
Zoladex
Zoledronic acid
Zolmitriptan
Zoloft
Zolpidem
Zometa
Zomig
Zonegran
Zonisamide
Zopiclone
Zosyn
Zovia
Zovirax
Zyban
Zymar
Zyprexa
Zyrtec
Zyvox

It was the first commercially available oxazolidinone antibiotic and is usually reserved for the treatment of serious bacterial infections where older antibiotics have failed due to antibiotic resistance. Conditions such as skin infections or nosocomial pneumonia where methicillin or penicillin resistance is found are indicators for linezolid use. Compared to the older antibiotics it is quite expensive.

The drug works by inhibiting the initiation of bacterial protein synthesis; it is the only antibiotic to work in this manner. That and its synthetic nature raised hopes that bacteria would be unable to develop resistance to it and also remove the chance of cross-resistance. (However, in 1997 Staphylococcus aureus was first identified in Japan as being resistant to linezolid.) Linezolid is effective against gram-positive pathogens, notably Enterococcus faecium, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, and Streptococcus pyogenes. It has almost no effect on gram-negative bacteria and is only bacteriostatic against most Enterococcus species.

The oxazolidinone class was discovered by researchers at E.I. duPont de Nemours and reported in 1987. Pharmacia Corporation developed linezolid and FDA approval was granted in April 2000. It is sold in the US under the tradename Zyvox in either tablet form, oral suspension powder, or in an inactive medium for intravenous injection.

Adverse effects

Side effects include rashes, loss of appetite, diarrhea, nausea, constipation and fever. A small number of patients will incur a severe allergic reaction, or tinnitis, or pseudomembranous colitis, or thrombocytopenia. Linezolid is a weak monoamine oxidase inhibitor (MAOI) and cannot be used with tyramine containing foods or pseudoephedrine.

Linezolid is toxic to mitochondria (probably because of the similarity of mitochondrial ribosomes to bacteria mitochondria). Signs of mitochondrial toxicity include lactic acidosis and peripheral neuropathy (Soriano et al., 2005).

Read more at Wikipedia.org


[List your site here Free!]


Linezolid Safe, Effective for Drug-Resistant Infections. : An article from: Family Practice News $5.95 Consider linezolid for treatment of resistant gram-positive infections: three formulations.(Dermatologi c Therapy) : An article from: Skin & Allergy News $5.95
Overuse of Zyvox tied to neuropathy.(Infectious Diseases) : An article from: Internal Medicine News $5.95 New Antibiotic Linezolid Is Approved by FDA.(Brief Article) : An article from: Family Practice News $5.95
MRSA skin infection Tx: 'old guys' still pack punch: 'don't reach for Zyvox for everybody'.(methicillin-r esistant Staphylococcus aureus) : An article from: Skin & Allergy News $5.95 Zyvox use for long periods tied to neuropathy onset.(News) : An article from: Skin & Allergy News $5.95

Oral Zyvox may keep some patients with antibiotic-resistant infections out of the hospital
DIABETIC FOOT ULCERS The FDA has approved the antibiotic Zyvox (linezolid injection, tablets, and oral suspension) for treatment of diabetic foot ulcers ...
Zyvox: Sound familiar?
Concern has been expressed about the use of Zyvox as the name for Pharmacia's new oral and LV antibiotic, linezolid. Zyvox may be misheard and confused ...
First Antibiotic in New Class of Drugs Fights Resistant Infections - antibacterial drug Zyvox approved by the FDA - Brief Article
The first in a new class of antibacterial drugs to treat serious infections resistant to other antibiotics has been approved by the Food and Drug Administration.
FDA approves Zyvox, first in new class of antibiotics - Brief Article
The FDA has approved Pharmacia Corp.'s Zyvox (linezolid injection, tablets and for oral suspension) for the treatment of patients with infections caused ...
Zyvox
(linezolid, Pharmacia) An antibacterial for adults with van-comycin-resistant Enterococcus faecium (VREF) infections, nosocomial pneumonia, and skin ...
Zyvox
(linezolid, Pharmacia) An antibacterial for adults with vancomycin-resistant Enterococus faecium (VREF) infections, nosocomial pneumonia, and skin ...
Will linezolid eradicate MRSA from surgical sites?
Site infections are a major cause of surgical morbidity. The proportion of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) has ...
IDSA releases guidelines on the diagnosis and treatment of diabetic foot infections
The Infectious Diseases Society of America (IDSA) has developed guidelines for the diagnosis and treatment of diabetic foot infections. The guidelines ...

Home Contact Resources Exchange Links ebay