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Fatty liver

Fatty liver or steatosis hepatis is a reversible condition seen in chronic alcoholism and many other conditions, where large vacuoles of lipid accumulate in hepatocytes (the cells of the liver). Accumulation of fat in liver cells will cause the liver to enlarge. The lipid within the vacuoles is a particular type of lipid known as triglyceride. Triglyceride molecules consist of a glycerol backbone with three fatty acid molecules joined on. more...

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Causes

Many chemicals, such as alcohol and drugs can cause fatty liver.

Fatty liver can occur in diabetes mellitus and in pregnancy. It can also be seen in starvation and obesity. In addition, it is also a minor symptom of hepatitis

Pathology

Fatty change represents the intracytoplasmic accumulation of triglyceride (neutral fats). At the beginning, the hepatocytes present small fat vacuoles (liposomes) around the nucleus - microvesicular fatty change. In the late stages, the size of the vacuoles increases pushing the nucleus to the periphery of the cell - macrovesicular fatty change. These vesicles are well delineated and optically "empty" because fats solves during tissue processing. Large vacuoles may coalesce, producing fatty cysts - which are irrevesible lesions. 1

Treatment and prevention

The treatment of fatty liver depends on what is causing it, and generally, treating the underlying cause will remove the problem.

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Fatty Liver Disease: NASH and Related Disorders $110.00 Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-[kappa]B pathway in rat liver. : An article from: Diabetes $5.95
Nonalcoholic Fatty Liver Pandemic Looms.(Brief Article) : An article from: Family Practice News $5.95 The fatty acid profile of buccal cheek cell phospholipids is a noninvasive marker of long-chain polyunsaturated fatty acid status in piglets : An article from: The Journal of Nutrition $20.00
Rising obesity rates boosting liver disease risk: the typical patient with nonalcoholic fatty liver disease has a BMI above 30 and insulin resistance.(Across ... : An article from: Clinical Psychiatry News $5.95 Nonalcoholic fatty liver disease in type 2: diabetes: obese adolescents.(Children's Health) : An article from: Family Practice News $5.95
Metabolism of cholesterol is altered in the liver of C3H mice fed fats enriched with different C-18 fatty acids : An article from: The Journal of Nutrition $20.00 Fatty liver disease common in U.S. adolescents.(Digestive Disorders) : An article from: Family Practice News $5.95
Trans-10,cis-12 conjugated linoleic acid suppresses the desaturation of linoleic and (alpha)-linolenic acids in HepG2 cells : An article from: The Journal of Nutrition $20.00 Trans polyunsaturated fatty acids have more adverse effects than saturated fatty acids on the concentration and composition of lipoproteins secreted by ... : An article from: The Journal of Nutrition $20.00

Management of non-alcoholic fatty liver disease in diabetes
Introduction: Clinical scenario A 41-year-old South Asian man attends your surgery with newly diagnosed type 2 diabetes, diagnosed by the nurse practitioner ...
Plasma lipid parameters in patients with alcoholic fatty liver after treatment with essential phospholipids
Turecky L, Kupcova V, Szantova M. Uhlikova E. Bratisl Lek Listy 2003:104:227-231. BACKGROUND: Fatty liver is the earliest and most common response ...
Weight loss for nonalcoholic fatty liver disease
Nonalcoholic fatty liver is defined as hepatic steatosis in the absence of alcohol use or another chronic liver disease. It is one of the most common ...
Fatty liver
Fatty liver is the collection of excessive amounts of triglycerides and other fats inside liver cells.
Transaminase levels and fatty liver disease - Medical News From Around World - serum transaminase; nonalocholic fatty liver disease
ITALY--Elevated serum transaminase levels are often found in patients who do not have diabetes or dyslipidemias, but the clinical significance of "nonalcoholic ...
Recognition of nonalcoholic fatty liver disease - Tips from Other Journals
Increased levels of liver transaminase in patients are commonly noted by family physicians. While many cases can be explained by previously undetected ...
Nonalcoholic fatty liver disease: relationship to insulin sensitivity and oxidative stress. Treatment spproaches using vitamin E, magnesium, and betaine
Abstract Nonalcoholic steatotic hepatitis (NASH), the most prevalent form of progressive liver disease in the United States, is considered to be a ...
The effects of pantethine on fatty liver and fat distribution - Abstracts: recently published abstracts - Brief Article
Although the prognosis of fatty liver depends on its causes, we feel from our clinical experience that fatty liver with hypertriglyceridemia has a good ...

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